Mammalian Genome 11, 247–249 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Cloning, structure and assignment to Chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14) 1 1 2 2 3 1 Christoph To ¨ pert, Frank Do ¨ ring, Christian Derst, Ju ¨ rgen Daut, Karl-Heinz Grzeschik, Andreas Karschin Max-Planck-Institute for Biophysical Chemistry, Molecular Neurobiology of Signal Transduction, 37070 Go ¨ ttingen, Germany Institute for Normal and Pathological Physiology, University of Marburg, 35033 Marburg, Germany Institute for Human Genetics, University of Marburg, 35033 Marburg, Germany Received: 1 September 1999 / Accepted: 12 November 1999 Inwardly rectifying K (Kir) channels are assembled from four and shares similar sequence identity with the guinea pig ortholog subunits, each consisting of two transmembrane segments flanking of Kir2.4 (Genbank accession number AF187876; Fig. 1A). a pore loop region. According to sequence similarity and func- Structural analysis of the human Kir2.4 gene (KCNJ14) re- tional properties, 15 differentially distributed subunits are now vealed the existence of an intron that disrupts the ORF at the codon grouped into six subfamilies (Kir1, Kir2, Kir3, Kir5, Kir6, and for glutamine 238. The intron is 1742 bp in length and is flanked Kir7).
Mammalian Genome – Springer Journals
Published: Feb 26, 2014
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