Mammalian Genome 12, 469–471 (2001). DOI: 10.1007/s003350020010 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Cloning of the rat agouti gene and identification of the rat nonagouti mutation Takashi Kuramoto, Tomoko Nomoto, Takashi Sugimura, Toshikazu Ushijima Carcinogenesis Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045 Japan Received: 1 November 2000 / Accepted: 1 February 2001 The agouti locus is one of the classic coat color loci of laboratory signed based on the positions of introns deduced from the se- animals such as mice and rats (Doolittle et al. 1996; RATMAP quences of the mouse agouti gene (Wilson et al. 1995), and PCR 2000). In the mouse, the agouti gene encodes a 131-amino acid was performed with the genomic DNAs from the ACI rat. Ap- paracrine signaling molecule whose pulsatile expression produces proximately 1.8-kb and 3.0-kb fragments were obtained from in- a characteristic pattern of banded pigment in individual hairs trons 2 and 3, respectively. However, no fragment was obtained (Bultman et al. 1992; Miller et al. 1993; Michaud et al. 1994). from intron 1. We determined the nucleotide sequences of the Gain-of-function mutation of mouse agouti, such as lethal-yellow splice donor and acceptor sites of
Mammalian Genome – Springer Journals
Published: Jun 1, 2001
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