Cloning of rat Brca2 and linkage mapping to Chromosome 12

Cloning of rat Brca2 and linkage mapping to Chromosome 12 Mammalian Genome 8, 850-851 (1997). e//o///e 9 Springer-Vertag New York Inc. 1997 Shin Yamada, 1'3 Hitoshi Nakagama, 2 Minoru Toyota, 1 Toshikazu Ushijima, 1 Kyoji Okada, 3 Kozo Sato, 3 Takashi Sugimura, 1 Minako Nagao I 1Carcinogenesis Division, National Cancer Center Research Institute, 1-1 Tsukiji 5, Chuo-ku, Tokyo, 104 Japan 2Biochemistry Division, National Cancer Center Research Institute, 1-I Tsukiji 5, Cbuo-ku, Tokyo, 104 Japan SDepartment of Orthopedic Surgery, Akita University School of Medicine, 1-1-1, Hondo, Akita, 0 l0 Japan Received: 12 February 1997 / Accepted: 14 July 1997 Approximately 5% of breast cancers, one of the most common partial fragment, BR2-1, was performed. BR2-1, which was 2529 causes of mortality in females, appear due to genetically inherited bp in size and contained a complete open reading frame with a traits. Mutations in BRCA1, a human breast- and ovarian-cancer predicted peptide 843 amino acids long, had a 67.8% nucleotide susceptibility gene identified on Chromosome (Chr) 17q, have identity with the middle part of exon 11 of human BRCA2. This been demonstrated to be responsible for many familial breast can- corresponded to amino acids 1119-1979 of the human BRCA2 cers, as well as familial and sporadic ovarian cancers (Miki et al. Mammalian Genome Springer Journals

Cloning of rat Brca2 and linkage mapping to Chromosome 12

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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