Mammalian Genome 8, 866-868 (1997). 9 Springer-Veflag New York lnc 1997 Cloning and mapping of the human SOXI: a highly conserved gene expressed in the developing brain S. Malas, 1 S. M. Duthie, 1 F. Mohri, 1 R. Lovell-Badge, 2 V. Episkopou 1 1MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, UK 2National Institute for Medical Research, The Ridgeway, Mill Hill London NW7 1AA, UK Received: 15 April 1997 / Accepted: 21 July 1997 The SOX proteins came to light after the isolation of the mamma- some distance, which may affect binding and interactions of other lian sex-determining gene, SRY (Gubbay et al. 1990; Sinclair et al. transcription factors (Grosschedl et al. 1994; Pontiggia et al. 1994). 1990). The SRY and SOX proteins share a DNA-binding domain So far, 20 Sox genes have been identified in mammals (Tani et al. known as the HMG-box, defined by a 79-amino acid region. All 1997), but only a few have been characterized in detail. SOX genes SOX proteins have a single HMG box and bind linear DNA in a are divided into subfamilies based on homology within the HMG sequence-specific manner, resulting in the bending of DNA
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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