Cloning and expression of ARMC3-v2, a novel splicing variant of human ARMC3 gene

Cloning and expression of ARMC3-v2, a novel splicing variant of human ARMC3 gene ARM genes, whose polypeptide consist of Armadillo/beta-catenin-like repeats (ARM) domain(s), exist ubiquitously from flies to vertebrates. These genes have multiple functions in signal transduction, development, cell adhesion and mobility, tumor initiation and metastasis. In this study, we have isolated a 2439-bp novel splicing variant of ARMC3 from the human fetal brain, encoding a 688-amino acid polypeptide that contains three typical ARM domains. The cDNA named ARMC3_v2 and the original named ARMC3_v1 (Gen-Bank: BC039312) are both located on the human chromosome 10p12.23. RT-PCR analysis in our work showed that ARMC3_v2 was detected in human skeletal muscle, liver, spleen and thymus; in contrast, ARMC3_v1 in skeletal muscle, lung, prostate and testis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Cloning and expression of ARMC3-v2, a novel splicing variant of human ARMC3 gene

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Publisher
Nauka/Interperiodica
Copyright
Copyright © 2006 by Pleiades Publishing, Inc.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795406070209
Publisher site
See Article on Publisher Site

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