Mammalian Genome 9, 921–924 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI 1 3 1,2 Elena V. Semina, Michael R. Altherr, Jeffrey C. Murray Department of Pediatrics, The University of Iowa, 200 Hawkins Drive, W229-1 GH, Iowa City, Iowa 52242-1083, USA Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA Genomics Group, Life Sciences Division, MS M888, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA Received: 2 June 1998 / Accepted: 10 July 1998 Genes encoding LIM-domain binding factors were initially iso- signal at position 2309, and poly(A)-tail of 23nt (Fig. 1A). CLIM2 lated in a screen for proteins that physically interact with the LIM composite cDNA was found to be 1953 bp in length with a po- domains of nuclear proteins (Agulnick et al. 1996; Jurata et al. tential initiation codon found at position 285, polyadenylation sig- 1996, Bach et al. 1997). These proteins are capable of binding to nal at position 1910, and poly(A)-tail of 18nt (Fig. 1B). Human a variety of transcription factors and are likely to function at en- CLIM1 and CLIM2
Mammalian Genome – Springer Journals
Published: Nov 1, 1998
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