Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family

Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family Here we report the cloning and primary characterization of TIC, a new member of the bHLH/PAS domain family of transcription factors. Northern blot analysis indicates that the 3.3-kb Tic mRNA is widely expressed. A polyclonal antibody against TIC identifies multiple protein species in most cell lines and tissues tested, suggesting that alternative splicing may result in the production of protein isoforms. Interspecies backcross and FISH mapping have been used to localize the Tic gene to mouse Chromosome (Chr) 7 F2-F3, given the locus name Arntl. FISH mapping was also used to localize the human gene to Chr 11p15. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family

Loading next page...
 
/lp/springer_journal/cloning-and-chromosomal-localization-of-a-new-member-of-the-bhlh-pas-yMxW6Nk8gX
Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900797
Publisher site
See Article on Publisher Site

Abstract

Here we report the cloning and primary characterization of TIC, a new member of the bHLH/PAS domain family of transcription factors. Northern blot analysis indicates that the 3.3-kb Tic mRNA is widely expressed. A polyclonal antibody against TIC identifies multiple protein species in most cell lines and tissues tested, suggesting that alternative splicing may result in the production of protein isoforms. Interspecies backcross and FISH mapping have been used to localize the Tic gene to mouse Chromosome (Chr) 7 F2-F3, given the locus name Arntl. FISH mapping was also used to localize the human gene to Chr 11p15.

Journal

Mammalian GenomeSpringer Journals

Published: Jun 1, 1998

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off