J. Membrane Biol. 160, 91–100 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review F. Soto, M. Garcia-Guzman*, W. Stu ¨ hmer Department of Molecular Biology of Neuronal Signals, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, D-37075 Go ¨ ttingen, Germany Received: 17 March 1997/Revised: 3 June 1997 Introduction stock, 1996; Burnstock & King, 1996). Studies on native P2 receptors defined an additional class represented by the P2Z receptor. Its activation leads to the opening of Adenosine 58 triphosphate (ATP) is copackaged in exo- large-conductance nonselective pores which results in cytotic granules and secreted with a number of neuro- cell lysis (Tatham & Landau, 1990). However, heterolo- transmitters and local mediators from many cell types gously expressed P2X receptor presents functional (Whittaker, 1982). Indeed, the exocytosis of ATP properties that strongly resembles the behavior of native evokes fast synaptic potentials in the central and periph- P2Z receptor (Surprenant et al., 1996a). eral nervous system (Edwards, Gibb & Colquhoun, The characterization of cloned P2X receptors con- 1992; Evans, Derkach & Surprenant, 1992; Silinsky, stitutes a basic framework for a precise description of Gerzanich & Vauner, 1992). ATP can also be released their physiological function. The
The Journal of Membrane Biology – Springer Journals
Published: Nov 15, 1997
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