Clofazimine/tigecycline

Clofazimine/tigecycline Reactions 1704, p112 - 2 Jun 2018 Various toxicities: case report A man in his late 40s [exact age at reaction onset not clearly stated] developed anorexia, weight loss, nausea, malaise, liver dysfunction and acute kidney injury during treatment with clofazimine and tigecycline [dosages and duration of treatments to reaction onsets not stated; not all routes stated]. The man underwent left total hip arthroplasty at the age of 48 years due to avascular necrosis of the left femoral head. Two weeks following the surgery, he underwent an open revision due to recurrent subluxation of the prosthesis. Additionally, he had a medical history of gout. Within a month of arthroplasty, he underwent trochanter advancement osteotomy because of prosthesis dislocation. One year later, he developed bulging cyst at the left hip, which was considered as haematoma. However, non-tuberculous mycobacteria (NTM) was cultured from the cyst fluid. Hence, empirical treatment was initiated. Later, Mycobacterium abscessus subspecies massiliense susceptible to clarithromycin and tigecycline was isolated. After one month, he discontinued anti-NTM treatment by himself. Few months later, he developed recurrent pain of the left hip and draining sinus tract. The pus grew Mycobacterium abscessus subspecies massiliense. Thereafter, the prosthesis was removed and treatment with IV tigecycline, clofazimine, clarithromycin and amikacin was initiated. He discontinued the therapy due to anorexia, weight loss, nausea, malaise, liver dysfunction and acute kidney injury. The man’s symptoms improved following the discontinuation of clofazimine and tigecycline. However, the same symptoms reappeared on re-challenge with tigecycline and clofazimine. Thereafter, he was started on oral suppressive anti-NTM therapy [final outcome not stated]. Author comment: "The patient again stopped anti-NTM therapy due to nausea, malaise, anorexia, weight loss, acute kidney injury and liver dysfunction. Symptoms improved after discontinuing clofazimine and tigecyline. The same symptoms appeared after rechallenge with clofazimine and tigecycline." Wang L-S, et al. Incurable hip prosthesis infection due to Mycobacterium abscessus subspecies massiliense. International Journal of Antimicrobial Agents 50 (Suppl. 2): S203 (plus poster) abstr. PS 356, Nov 2017. Available from: URL: https://doi.org/10.1016/S0924-8579(17)30423-5 [abstract] - Taiwan 803324001 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Clofazimine/tigecycline

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46755-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p112 - 2 Jun 2018 Various toxicities: case report A man in his late 40s [exact age at reaction onset not clearly stated] developed anorexia, weight loss, nausea, malaise, liver dysfunction and acute kidney injury during treatment with clofazimine and tigecycline [dosages and duration of treatments to reaction onsets not stated; not all routes stated]. The man underwent left total hip arthroplasty at the age of 48 years due to avascular necrosis of the left femoral head. Two weeks following the surgery, he underwent an open revision due to recurrent subluxation of the prosthesis. Additionally, he had a medical history of gout. Within a month of arthroplasty, he underwent trochanter advancement osteotomy because of prosthesis dislocation. One year later, he developed bulging cyst at the left hip, which was considered as haematoma. However, non-tuberculous mycobacteria (NTM) was cultured from the cyst fluid. Hence, empirical treatment was initiated. Later, Mycobacterium abscessus subspecies massiliense susceptible to clarithromycin and tigecycline was isolated. After one month, he discontinued anti-NTM treatment by himself. Few months later, he developed recurrent pain of the left hip and draining sinus tract. The pus grew Mycobacterium abscessus subspecies massiliense. Thereafter, the prosthesis was removed and treatment with IV tigecycline, clofazimine, clarithromycin and amikacin was initiated. He discontinued the therapy due to anorexia, weight loss, nausea, malaise, liver dysfunction and acute kidney injury. The man’s symptoms improved following the discontinuation of clofazimine and tigecycline. However, the same symptoms reappeared on re-challenge with tigecycline and clofazimine. Thereafter, he was started on oral suppressive anti-NTM therapy [final outcome not stated]. Author comment: "The patient again stopped anti-NTM therapy due to nausea, malaise, anorexia, weight loss, acute kidney injury and liver dysfunction. Symptoms improved after discontinuing clofazimine and tigecyline. The same symptoms appeared after rechallenge with clofazimine and tigecycline." Wang L-S, et al. Incurable hip prosthesis infection due to Mycobacterium abscessus subspecies massiliense. International Journal of Antimicrobial Agents 50 (Suppl. 2): S203 (plus poster) abstr. PS 356, Nov 2017. Available from: URL: https://doi.org/10.1016/S0924-8579(17)30423-5 [abstract] - Taiwan 803324001 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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