Clocks go forward: progress in the molecular genetic analysis of rhythmic behaviour

Clocks go forward: progress in the molecular genetic analysis of rhythmic behaviour The molecular basis of circadian homeostasis has proven to be amenable to genetic dissection in many model organisms. Surprisingly, additional factors contributing to an organism’s “chronotype” continue to be identified using both forward and reverse genetics. As more factors are identified, the importance of rhythm regulation in all body systems is becoming apparent. Moreover, recent evidence confirms that the regulation of circadian homeostasis can be fine-tuned at a number of molecular levels. This not only ensures that biological rhythms are maintained at a robust level in all cells but also allows for the precise and rapid readjustment of rhythms in response to environmental factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Clocks go forward: progress in the molecular genetic analysis of rhythmic behaviour

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Publisher
Springer-Verlag
Copyright
Copyright © 2009 by Springer Science+Business Media, LLC
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-008-9166-1
Publisher site
See Article on Publisher Site

Abstract

The molecular basis of circadian homeostasis has proven to be amenable to genetic dissection in many model organisms. Surprisingly, additional factors contributing to an organism’s “chronotype” continue to be identified using both forward and reverse genetics. As more factors are identified, the importance of rhythm regulation in all body systems is becoming apparent. Moreover, recent evidence confirms that the regulation of circadian homeostasis can be fine-tuned at a number of molecular levels. This not only ensures that biological rhythms are maintained at a robust level in all cells but also allows for the precise and rapid readjustment of rhythms in response to environmental factors.

Journal

Mammalian GenomeSpringer Journals

Published: Jan 15, 2009

References

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