Ann Surg Oncol (2017) 24:2588–2594 DOI 10.1245/s10434-017-5987-z OR IGINAL ARTIC L E – COLORECTAL CANCER Clinicopathological Determinants of an Elevated Systemic Inﬂammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer 1 1 1 David G. Watt, MBChB , Michelle L. Ramanathan, PhD , Stephen T. McSorley, MBChB , Killian Walley, 2 1 1 1 MBChB , James H. Park, MBChB , Paul G. Horgan, PhD , and Donald C. McMillan, PhD 1 2 Academic Unit of Surgery, R2.06, School of Medicine—University of Glasgow, Glasgow, UK; Department of Surgery, Glasgow Royal Inﬁrmary, Glasgow, UK ABSTRACT 1.06–2.57; p = 0.028), mGPS (HR 1.81; CI 1.22–2.68; Introduction. The postoperative systemic inﬂammatory p = 0.003), NLR (HR 0.50; CI 0.26–0.95; p = 0.034), and response (SIR) is related to both long- and short-term tumour site (HR 2.90; CI 1.49–5.65; p = 0.002). outcomes following surgery for colorectal cancer. How- Conclusions. ASA grade, BMI, mGPS, and tumour site ever, it is not clear which clinicopathological factors are were consistently associated with the magnitude of the associated with the magnitude of the postoperative SIR. postoperative systemic inﬂammatory response, evidenced The present study was designed to determine the clinico- by a high poGPS on days
Annals of Surgical Oncology – Springer Journals
Published: Jul 10, 2017
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