Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer

Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective... Ann Surg Oncol (2017) 24:2588–2594 DOI 10.1245/s10434-017-5987-z OR IGINAL ARTIC L E – COLORECTAL CANCER Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer 1 1 1 David G. Watt, MBChB , Michelle L. Ramanathan, PhD , Stephen T. McSorley, MBChB , Killian Walley, 2 1 1 1 MBChB , James H. Park, MBChB , Paul G. Horgan, PhD , and Donald C. McMillan, PhD 1 2 Academic Unit of Surgery, R2.06, School of Medicine—University of Glasgow, Glasgow, UK; Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK ABSTRACT 1.06–2.57; p = 0.028), mGPS (HR 1.81; CI 1.22–2.68; Introduction. The postoperative systemic inflammatory p = 0.003), NLR (HR 0.50; CI 0.26–0.95; p = 0.034), and response (SIR) is related to both long- and short-term tumour site (HR 2.90; CI 1.49–5.65; p = 0.002). outcomes following surgery for colorectal cancer. How- Conclusions. ASA grade, BMI, mGPS, and tumour site ever, it is not clear which clinicopathological factors are were consistently associated with the magnitude of the associated with the magnitude of the postoperative SIR. postoperative systemic inflammatory response, evidenced The present study was designed to determine the clinico- by a high poGPS on days http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgical Oncology Springer Journals

Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
1068-9265
eISSN
1534-4681
D.O.I.
10.1245/s10434-017-5987-z
Publisher site
See Article on Publisher Site

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