Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis

Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups [Odds ratio 0.21, 95% confidence interval (CI) 0.0723–0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893–0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Cell Springer Journals

Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis

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Publisher
Springer Japan
Copyright
Copyright © 2018 by Japan Human Cell Society and Springer Japan KK, part of Springer Nature
Subject
Life Sciences; Cell Biology; Embryology; Oncology; Stem Cells; Reproductive Medicine; Cell Culture
eISSN
1749-0774
D.O.I.
10.1007/s13577-018-0200-7
Publisher site
See Article on Publisher Site

Abstract

To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups [Odds ratio 0.21, 95% confidence interval (CI) 0.0723–0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893–0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis.

Journal

Human CellSpringer Journals

Published: Jan 23, 2018

References

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