Gastric Cancer (2017) 20:802–810 DOI 10.1007/s10120-017-0705-x O R I G IN AL ARTI CL E Clinical signiﬁcance of altering epithelial–mesenchymal transition in metastatic lymph nodes of gastric cancer 1 1,2 1,2 1 • • • • Keishi Okubo Yoshikazu Uenosono Takaaki Arigami Shigehiro Yanagita 1 1 1 1 • • • • Daisuke Matsushita Takashi Kijima Masahiko Amatatsu Yasuto Uchikado 1 1 1,2 • • Yuko Kijima Kosei Maemura Shoji Natsugoe Received: 29 December 2016 / Accepted: 18 February 2017 / Published online: 28 February 2017 The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2017 Abstract stage. The strong expression of Snail in tumors and its weak Background The E-cadherin, N-cadherin, and Snail genes are expression in lymph nodes correlated with more lymph node epithelial–mesenchymal transition (EMT)-inducible genes. metastasis, an advanced stage, and poor prognosis. Previous studies demonstrated that the expression of EMT Conclusions The expression of N-cadherin in metastatic markers in the primary tumor sites of gastric cancer correlates lymph nodes is useful for predicting the prognosis of patients with tumor progression and prognosis. However, the clinical with gastric cancer. The Snail switch—namely, the positive- signiﬁcance of the expression of these EMT markers in meta-
Gastric Cancer – Springer Journals
Published: Feb 28, 2017
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