Int Urol Nephrol (2017) 49:1527–1536 DOI 10.1007/s11255-017-1629-4 UROLOGY - ORIGINAL PAPER Clinical presentations and molecular studies of invasive renal epithelioid angiomyolipoma 1 1 1 1 Cheng‑Keng Chuang · Hsin Chia Angela Lin · Han‑Yu Tasi · Kun‑Han Lee · 1 1 1 1 Yuting Kao · Fukai Leo Chuang · Ying‑Hsu Chang · Po‑Hung Lin · 1 1 Chung‑Yi Liu · See‑Tong Pang Received: 28 January 2017 / Accepted: 19 May 2017 / Published online: 25 May 2017 © Springer Science+Business Media Dordrecht 2017 Abstract Keywords Angiomyolipoma · Kidney · Next-generation Purpose Epithelioid angiomyolipoma (EAML) is a rare sequencing · Mammalian target of rapamycin · Metastasis variant of renal angiomyolipoma with malignant poten- tial, and the cytogenetic and clinical behavior of EAML remains a challenging issue. Introduction Methods We retrospectively analyze the clinical courses of five EAML, the use of everolimus on metastatic EAML, Renal angiomyolipoma (AML) is a benign mesenchymal and next-generation sequencing (NGS) and polymerase tumor composed of abnormal thick-walled blood vessels, chain reaction (PCR) studies to investigate the gene muta- smooth muscle cells and adipose tissue [1, 2]. Most renal tion of TSC and the impact of PI3K/Akt/mTOR signaling AMLs are sporadic, but some are associated
International Urology and Nephrology – Springer Journals
Published: May 25, 2017
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