Clinical impact of PET/CT imaging after adjuvant therapy in patients with oral cavity squamous cell carcinoma

Clinical impact of PET/CT imaging after adjuvant therapy in patients with oral cavity squamous... Purpose This single-center retrospective study of prospec- OSCC who developed recurrences following adjuvant therapy tively collected data was aimed at comparing the clinical out- (51 in Group A and 60 in Group B). Histopathology served as comes of positron emission tomography/computed tomogra- the gold standard for recurrent lesions. The impact of post- phy (PET/CT) for patients with oral cavity squamous cell adjuvant therapy PET/CT surveillance was examined with carcinoma (OSCC) with symptomatic recurrences identified Kaplan-Meier curves and Cox proportional hazards regression by PET/CT imaging following adjuvant therapy (Group A) models. versus those of cases with asymptomatic recurrences diag- Results The 2-year DSS and OS rates were marginally or significantly higher in Group B than in Group A (P =0.073 nosed through periodic post-adjuvant therapy PET/CT sur- veillance (Group B). We also sought to establish the priority and P = 0.025, respectively). Time-dependent ROC curve analysis demonstrated that the optimal cutoff values for time of salvage therapy in the two study groups. to positive PET/CT findings in relation to OS were 12 months for Group A and 9 months for Group B, respectively. Huan-Chun Lin and Chung-Jan Kang contributed equally to this work. Independent risk factors identified in multivariate analyses http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

Clinical impact of PET/CT imaging after adjuvant therapy in patients with oral cavity squamous cell carcinoma

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1619-7070
eISSN
1619-7089
D.O.I.
10.1007/s00259-017-3713-5
Publisher site
See Article on Publisher Site

Abstract

Purpose This single-center retrospective study of prospec- OSCC who developed recurrences following adjuvant therapy tively collected data was aimed at comparing the clinical out- (51 in Group A and 60 in Group B). Histopathology served as comes of positron emission tomography/computed tomogra- the gold standard for recurrent lesions. The impact of post- phy (PET/CT) for patients with oral cavity squamous cell adjuvant therapy PET/CT surveillance was examined with carcinoma (OSCC) with symptomatic recurrences identified Kaplan-Meier curves and Cox proportional hazards regression by PET/CT imaging following adjuvant therapy (Group A) models. versus those of cases with asymptomatic recurrences diag- Results The 2-year DSS and OS rates were marginally or significantly higher in Group B than in Group A (P =0.073 nosed through periodic post-adjuvant therapy PET/CT sur- veillance (Group B). We also sought to establish the priority and P = 0.025, respectively). Time-dependent ROC curve analysis demonstrated that the optimal cutoff values for time of salvage therapy in the two study groups. to positive PET/CT findings in relation to OS were 12 months for Group A and 9 months for Group B, respectively. Huan-Chun Lin and Chung-Jan Kang contributed equally to this work. Independent risk factors identified in multivariate analyses

Journal

European Journal of Nuclear Medicine and Molecular ImagingSpringer Journals

Published: May 26, 2017

References

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