Purpose This single-center retrospective study of prospec- OSCC who developed recurrences following adjuvant therapy tively collected data was aimed at comparing the clinical out- (51 in Group A and 60 in Group B). Histopathology served as comes of positron emission tomography/computed tomogra- the gold standard for recurrent lesions. The impact of post- phy (PET/CT) for patients with oral cavity squamous cell adjuvant therapy PET/CT surveillance was examined with carcinoma (OSCC) with symptomatic recurrences identified Kaplan-Meier curves and Cox proportional hazards regression by PET/CT imaging following adjuvant therapy (Group A) models. versus those of cases with asymptomatic recurrences diag- Results The 2-year DSS and OS rates were marginally or significantly higher in Group B than in Group A (P =0.073 nosed through periodic post-adjuvant therapy PET/CT sur- veillance (Group B). We also sought to establish the priority and P = 0.025, respectively). Time-dependent ROC curve analysis demonstrated that the optimal cutoff values for time of salvage therapy in the two study groups. to positive PET/CT findings in relation to OS were 12 months for Group A and 9 months for Group B, respectively. Huan-Chun Lin and Chung-Jan Kang contributed equally to this work. Independent risk factors identified in multivariate analyses
European Journal of Nuclear Medicine and Molecular Imaging – Springer Journals
Published: May 26, 2017
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