original article Wien Klin Wochenschr (2017) 129:552–557 DOI 10.1007/s00508-017-1208-9 Clinical and serological autoimmune complications in chronic lymphocytic leukemia Cengiz Demir · Ömer Ekinci Received: 16 November 2016 / Accepted: 12 April 2017 / Published online: 5 May 2017 © Springer-Verlag Wien 2017 Summary so with non-hematologic AIC. The latter complica- Background Autoimmune disorders often develop tions should be carefully searched for, particularly in during the course of chronic lymphocytic leukemia patients with early CLL. (CLL). The aim of our study was to investigate the incidence of autoimmune complications (AIC) and Keywords Chronic lymphocytic leukemia · Non- serological autoantibodies, and to assess the relation- hematological autoimmunity · Thrombocytopenia · ship of these to patient characteristics. Hemolytic anemia Methods We prospectively collected screenings of AIC and serological markers from a total of 192 patients. Introduction Results AIC was observed in 18 (9.4%) patients. Au- toimmune hemolytic anemia (AIHA) was observed in Chronic lymphocytic leukemia (CLL) is characterized 8 patients. Autoimmune thrombocytopenia (AITP) by the progressive deposition of monoclonal lympho- was observed in 3 patients. Other various types of AIC cytes with speciﬁc immunophenotypic features (i. e., were observed in the remaining 7 patients. Serological CD5+, CD19+, CD20, CD23+, and SmIg) in
Wiener klinische Wochenschrift – Springer Journals
Published: May 5, 2017
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