Clinical and MRI improvement in a case of progressive multifocal leukoencephalopathy

Clinical and MRI improvement in a case of progressive multifocal leukoencephalopathy Neurol Sci (2017) 38:1517–1519 DOI 10.1007/s10072-017-2914-9 LETTER TO THE EDITOR Clinical and MRI improvement in a case of progressive multifocal leukoencephalopathy 1 2 2 3 • • • • Letizia Tirelli Francesca Rosini Alessandra Rufa Guido Garosi 4 1 5 • • Alfonso Cerase Antonio Federico Andrea De Luca Received: 21 February 2017 / Accepted: 13 March 2017 / Published online: 18 April 2017 Springer-Verlag Italia 2017 Dear editor, combination with mirtazapine, an agonist of serotonin-re- ceptor-2A (5HT2AR) blocking the JCV entry into glial Progressive multifocal leukoencephalopathy (PML) is a cells. Although the restoration of host adaptive-immune severe demyelinating CNS disease due to lytic infection of response is the first purpose of PML therapy, a paradoxical oligodendrocytes by the John Cunningham polyomavirus excess of immune reconstitution may cause the PML-im- (JCV), an opportunistic agent requiring immunosuppres- mune reconstitution inflammatory syndrome (PML-IRIS). sion to become active, commonly complicating HIV In this condition, the administration of intravenous corti- infections, lymphoproliferative disorders or immunosup- costeroids is associated with a more favourable outcome pressive therapies [1]. PML has been reported in immune- [3]. Here we report the first PML-IRIS in an SLE patient, mediated rheumatologic disorders, such as systemic lupus responsive to treatment http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurological Sciences Springer Journals

Clinical and MRI improvement in a case of progressive multifocal leukoencephalopathy

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Publisher
Springer Milan
Copyright
Copyright © 2017 by Springer-Verlag Italia
Subject
Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Psychiatry
ISSN
1590-1874
eISSN
1590-3478
D.O.I.
10.1007/s10072-017-2914-9
Publisher site
See Article on Publisher Site

Abstract

Neurol Sci (2017) 38:1517–1519 DOI 10.1007/s10072-017-2914-9 LETTER TO THE EDITOR Clinical and MRI improvement in a case of progressive multifocal leukoencephalopathy 1 2 2 3 • • • • Letizia Tirelli Francesca Rosini Alessandra Rufa Guido Garosi 4 1 5 • • Alfonso Cerase Antonio Federico Andrea De Luca Received: 21 February 2017 / Accepted: 13 March 2017 / Published online: 18 April 2017 Springer-Verlag Italia 2017 Dear editor, combination with mirtazapine, an agonist of serotonin-re- ceptor-2A (5HT2AR) blocking the JCV entry into glial Progressive multifocal leukoencephalopathy (PML) is a cells. Although the restoration of host adaptive-immune severe demyelinating CNS disease due to lytic infection of response is the first purpose of PML therapy, a paradoxical oligodendrocytes by the John Cunningham polyomavirus excess of immune reconstitution may cause the PML-im- (JCV), an opportunistic agent requiring immunosuppres- mune reconstitution inflammatory syndrome (PML-IRIS). sion to become active, commonly complicating HIV In this condition, the administration of intravenous corti- infections, lymphoproliferative disorders or immunosup- costeroids is associated with a more favourable outcome pressive therapies [1]. PML has been reported in immune- [3]. Here we report the first PML-IRIS in an SLE patient, mediated rheumatologic disorders, such as systemic lupus responsive to treatment

Journal

Neurological SciencesSpringer Journals

Published: Apr 18, 2017

References

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