Clinical and histopathological analysis of 790 naevi
excised from 509 patients due to cosmetic reasons
Mehmet Can Saki
Received: 24 October 2014 /Accepted: 11 November 2014 /Published online: 4 December 2014
Springer-Verlag Berlin Heidelberg 2014
Background The risk of malignant transformation is the most
important reason for melanocytic naevi excision whereas the
most common reason for excision is cosmetic disturbance.
Methods Our study was conducted in a retrospective design
from June 2009 to October 2013 involving 790 naevi exci-
sions from 509 patients (332 male, 177 female) due to cos-
metic disturbance. Each patient was evaluated for age and
gender in addition to the clinical characteristics of the lesions
such as location, size, depth and morphology.
Results The average age of our patient group was 36.4 (18–68).
Of the 509 patients, 332 were female (65.2 %) and 177 were
male (34.7 %). Intradermal naevus was the most common type.
Of all patients, 93.3 % had intradermal, dysplastic or compound
naevi. Of all lesions, 93.9 % were intradermal, dysplastic or
compound naevi. Buccal region was the most common exci-
sion site in the face with 112 excisions. Female gender was
dominant in all naevi types except for dysplastic naevi and
junctional naevi. Male gender was dominant in these groups.
Conclusions Gender and age in addition to the clinical char-
acteristics of the lesion such as location, size, depth and
morphology were analysed for each patient. To our knowl-
edge, our study has the largest naevi excision number per-
formed for only cosmetic reasons. Even though there was no
malignant melanoma identified, high rate of dysplastic naevi
was an important data due to its malignancy risk.
Level of Evidence: Level III, risk/prognostic study.
Keywords Dysplastic naevus
Melanocytic naevus (MN) is a normal benign proliferation of
melanocytes which may be acquired or congenital. Whether
acquired or congenital, melanocytic nevi may pose an aesthet-
ic problem for many patients especially for women.
Melanocytic naevi are common and can be found anywhere
on the skin . Although the risk of a naevus evolving into a
melanoma is extremely small, melanocytic naevi are both risk
factors for melanoma and precursors of melanoma. It may be
difficult to distinguish between the two lesions either clinical-
ly or histologically. Although most melanocytic naevi are
stable and do not progress to malignancy, some naevi could
be considered important risk markers and potential precursors
of malignant melanoma (MM) .
An increased number of MN has been suggested as a strong
risk factor for MM ; sun exposure was considered the main
environmental risk factor for the development of both MN and
MM . Age, skin type, sun exposure, hormones and
immunsuppression are important ethiological factors for
evolving melanocytic naevus [5, 6]. Sun exposure especially
in the first 2 years of life still keeps the feature of being the
main risk factor of developing melanocytic neavi. The more
sun exposure for the children, the higher risk of developing
melanocytic neavi . It is also known that intermittent sun
exposure has a higher risk of developing melanocytic naevi
from chronic sun exposure [6, 7].
Since it is an extremely common lesion, clinically often
disfiguring, many patients desire cosmetic removal of their
naevi. Removal of a melanocytic naevus whether congenital
B. Ersen (*)
M. C. Saki
Faculty of Medicine, Plastic Aesthetic and Reconstructive Surgery
Department, Uludag University, Bursa, Turkey
Eur J Plast Surg (2015) 38:133–138