Adv Ther (2017) 34:1775–1790 DOI 10.1007/s12325-017-0569-9 REVIEW Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efﬁcacy and Healthcare Resource Utilization for Seven Key Indications . . Michael Philbin John Niewoehner George J. Wan Received: May 1, 2017 / Published online: June 28, 2017 The Author(s) 2017. This article is an open access publication on RCI treatment of seven disorders: infantile ABSTRACT spasms (IS), multiple sclerosis (MS) relapses, proteinuria in nephrotic syndrome, rheumatoid Introduction: Repository corticotropin injec- arthritis (RA), dermatomyositis/polymyositis tion (RCI; H.P. Acthar Gel; Mallinckrodt (DM/PM), systemic lupus erythematosus (SLE), Pharmaceuticals Inc., Hampton, NJ) is a highly and symptomatic sarcoidosis based on pub- puriﬁed, prolonged-release porcine preparation lished literature and product information. An of adrenocorticotropic hormone (ACTH) ana- extended report is available as the Academy of logue that is FDA-approved for treatment of 19 Managed Care Pharmacy (AMCP) Formulary autoimmune and inﬂammatory disorders. The dossier for H.P. Acthar Gel. diverse physiological actions of RCI at the Methods: Key studies of clinical efﬁcacy and melanocortin receptors (MCRs) affect processes healthcare utilization and cost from 1956 to involved in inﬂammation, pigmentation, 2016 are summarized. steroidogenesis, and immunomodulation. Results: The evidence supports the efﬁcacy of Although
Advances in Therapy – Springer Journals
Published: Jun 28, 2017
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