Citalopram/donepezil/memantine

Citalopram/donepezil/memantine Reactions 1704, p104 - 2 Jun 2018 Prolonged QTc and bradycardia: case report A 74-year-old woman developed bradycardia and prolonged QTc during treatment with citalopram, donepezil and memantine [routes and frequency of administration not stated]. The woman with a medical history of moderate Alzheimer’s dementia, hypertension and depression presented for a routine follow-up. She had been receiving citalopram 30mg, donepezil 10mg and memantine 10mg for moderate Alzheimer’s dementia and depression. There was improvement in her condition. However, during the follow-up, she was noted to have bradycardia and an EKG demonstrated significant prolonged QTc of 502ms. The woman’s dose of citalopram was reduced to 20mg daily. At one month follow-up, her mood remained stable and there was slight improvement in her EKG with QTc of 459ms. Author comment: "We present a case of a previously diagnosed AZD patient with behavioral disturbances and depression that presented with side effects from therapy." "[O]nly remarkable for new bradycardia of 55 beats per minute and with EKG significant for prolonged QTc of 502ms." "A month after. . .her EKG slightly improved". Bhat AG, et al. Management road block in dementia. Journal of the American Geriatrics Society 66 (Suppl. 2): S255-S256, Apr 2018. Available from: URL: http://doi.org/10.1111/jgs.15376 [abstract] - USA 803323445 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Citalopram/donepezil/memantine

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46747-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p104 - 2 Jun 2018 Prolonged QTc and bradycardia: case report A 74-year-old woman developed bradycardia and prolonged QTc during treatment with citalopram, donepezil and memantine [routes and frequency of administration not stated]. The woman with a medical history of moderate Alzheimer’s dementia, hypertension and depression presented for a routine follow-up. She had been receiving citalopram 30mg, donepezil 10mg and memantine 10mg for moderate Alzheimer’s dementia and depression. There was improvement in her condition. However, during the follow-up, she was noted to have bradycardia and an EKG demonstrated significant prolonged QTc of 502ms. The woman’s dose of citalopram was reduced to 20mg daily. At one month follow-up, her mood remained stable and there was slight improvement in her EKG with QTc of 459ms. Author comment: "We present a case of a previously diagnosed AZD patient with behavioral disturbances and depression that presented with side effects from therapy." "[O]nly remarkable for new bradycardia of 55 beats per minute and with EKG significant for prolonged QTc of 502ms." "A month after. . .her EKG slightly improved". Bhat AG, et al. Management road block in dementia. Journal of the American Geriatrics Society 66 (Suppl. 2): S255-S256, Apr 2018. Available from: URL: http://doi.org/10.1111/jgs.15376 [abstract] - USA 803323445 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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