Reactions 1704, p104 - 2 Jun 2018
Prolonged QTc and bradycardia: case report
A 74-year-old woman developed bradycardia and prolonged
QTc during treatment with citalopram, donepezil and
memantine [routes and frequency of administration not
The woman with a medical history of moderate Alzheimer’s
dementia, hypertension and depression presented for a
routine follow-up. She had been receiving citalopram 30mg,
donepezil 10mg and memantine 10mg for moderate
Alzheimer’s dementia and depression. There was
improvement in her condition. However, during the follow-up,
she was noted to have bradycardia and an EKG demonstrated
significant prolonged QTc of 502ms.
The woman’s dose of citalopram was reduced to 20mg
daily. At one month follow-up, her mood remained stable and
there was slight improvement in her EKG with QTc of 459ms.
Author comment: "We present a case of a previously
diagnosed AZD patient with behavioral disturbances and
depression that presented with side effects from therapy."
"[O]nly remarkable for new bradycardia of 55 beats per
minute and with EKG significant for prolonged QTc of
502ms." "A month after. . .her EKG slightly improved".
Bhat AG, et al. Management road block in dementia. Journal of the American
Geriatrics Society 66 (Suppl. 2): S255-S256, Apr 2018. Available from: URL:
http://doi.org/10.1111/jgs.15376 [abstract] - USA
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved