Cisplatin/fluorouracil

Cisplatin/fluorouracil Reactions 1704, p102 - 2 Jun 2018 Squamous cell carcinoma of the oesophagus with epidermization: case report A 57-year-old man developed squamous cell carcinoma of the oesophagus with epidermization during treatment with cisplatin [CDDP] and fluorouracil [5-fluorouracil; routes and dosages not stated]. The man had undergone endoscopic submucosal dissection for early esophageal cancer at the age of 50 years. Pathological findings revealed squamous cell carcinoma invading the lamina muscularis mucosae and mild lymphatic invasion. Considering the possibility of lymph node metastasis and distant metastasis, he started receiving cisplatin and fluorouracil with total radiation in the same year. Two years later, a follow-up endoscopy showed a white, flat, elevated lesion in the thoracic oesophagus that was not stained by Lugol’s iodine. A biopsy of this lesion was performed. Oesophageal epidermization was observed; however, no findings suggestive of malignancy were noted. The lesion grew slightly during four and a half years of follow-up after the identification. After a repeat biopsy, this lesion was diagnosed as atypical epithelium with epidermization. As a result, the man underwent endoscopic mucosal resection (EMR) for diagnostic and therapeutic purposes. Based on the histological features of the resected specimen, the post-operative pathological diagnosis was T1N0M0 Stage IA squamous cell carcinoma of the oesophagus with epidermization. He showed no tumour recurrence 8 months after EMR. Author comment: "To the best of our knowledge, this is the first report of esophageal cancer accompanied by epidermization." "It is important to note that because this patient had a history of chemoradiation therapy before this endoscopic treatment, it is possible that chemoradiation therapy influenced the development of epidermization and/or esophageal cancer." Yamanouchi S, et al. Early esophageal cancer with epidermization diagnosed and treated with endoscopic resection. Clinical Journal of Gastroenterology 11: 29-33, No. 1, Feb 2018. Available from: URL: http://doi.org/10.1007/s12328-017-0792-6 - Japan 803324045 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Cisplatin/fluorouracil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46745-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p102 - 2 Jun 2018 Squamous cell carcinoma of the oesophagus with epidermization: case report A 57-year-old man developed squamous cell carcinoma of the oesophagus with epidermization during treatment with cisplatin [CDDP] and fluorouracil [5-fluorouracil; routes and dosages not stated]. The man had undergone endoscopic submucosal dissection for early esophageal cancer at the age of 50 years. Pathological findings revealed squamous cell carcinoma invading the lamina muscularis mucosae and mild lymphatic invasion. Considering the possibility of lymph node metastasis and distant metastasis, he started receiving cisplatin and fluorouracil with total radiation in the same year. Two years later, a follow-up endoscopy showed a white, flat, elevated lesion in the thoracic oesophagus that was not stained by Lugol’s iodine. A biopsy of this lesion was performed. Oesophageal epidermization was observed; however, no findings suggestive of malignancy were noted. The lesion grew slightly during four and a half years of follow-up after the identification. After a repeat biopsy, this lesion was diagnosed as atypical epithelium with epidermization. As a result, the man underwent endoscopic mucosal resection (EMR) for diagnostic and therapeutic purposes. Based on the histological features of the resected specimen, the post-operative pathological diagnosis was T1N0M0 Stage IA squamous cell carcinoma of the oesophagus with epidermization. He showed no tumour recurrence 8 months after EMR. Author comment: "To the best of our knowledge, this is the first report of esophageal cancer accompanied by epidermization." "It is important to note that because this patient had a history of chemoradiation therapy before this endoscopic treatment, it is possible that chemoradiation therapy influenced the development of epidermization and/or esophageal cancer." Yamanouchi S, et al. Early esophageal cancer with epidermization diagnosed and treated with endoscopic resection. Clinical Journal of Gastroenterology 11: 29-33, No. 1, Feb 2018. Available from: URL: http://doi.org/10.1007/s12328-017-0792-6 - Japan 803324045 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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