Reactions 1704, p102 - 2 Jun 2018
Squamous cell carcinoma of the oesophagus with
epidermization: case report
A 57-year-old man developed squamous cell carcinoma of
the oesophagus with epidermization during treatment with
cisplatin [CDDP] and fluorouracil [5-fluorouracil; routes and
dosages not stated].
The man had undergone endoscopic submucosal dissection
for early esophageal cancer at the age of 50 years. Pathological
findings revealed squamous cell carcinoma invading the
lamina muscularis mucosae and mild lymphatic invasion.
Considering the possibility of lymph node metastasis and
distant metastasis, he started receiving cisplatin and
fluorouracil with total radiation in the same year. Two years
later, a follow-up endoscopy showed a white, flat, elevated
lesion in the thoracic oesophagus that was not stained by
Lugol’s iodine. A biopsy of this lesion was performed.
Oesophageal epidermization was observed; however, no
findings suggestive of malignancy were noted. The lesion grew
slightly during four and a half years of follow-up after the
identification. After a repeat biopsy, this lesion was diagnosed
as atypical epithelium with epidermization.
As a result, the man underwent endoscopic mucosal
resection (EMR) for diagnostic and therapeutic purposes.
Based on the histological features of the resected specimen,
the post-operative pathological diagnosis was T1N0M0
Stage IA squamous cell carcinoma of the oesophagus with
epidermization. He showed no tumour recurrence 8 months
Author comment: "To the best of our knowledge, this is
the first report of esophageal cancer accompanied by
epidermization." "It is important to note that because this
patient had a history of chemoradiation therapy before this
endoscopic treatment, it is possible that chemoradiation
therapy influenced the development of epidermization and/or
Yamanouchi S, et al. Early esophageal cancer with epidermization diagnosed and
treated with endoscopic resection. Clinical Journal of Gastroenterology 11: 29-33,
No. 1, Feb 2018. Available from: URL: http://doi.org/10.1007/s12328-017-0792-6
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved