Reactions 1704, p100 - 2 Jun 2018 Leucopenia and oesophageal fistula: 2 case reports In a retrospective study involving 76 patients, two patients [ages and sexes not stated] were described, who developed leucopenia or oesophageal fistula during treatment with fluorouracil [5-fluorouracil] and cisplatin for stage I II squamous cell oesophageal cancer. The patients with histologically proven stage I II squamous cell carcinoma of the oesophagus, started receiving concurrent chemoradiotherapy. The patients started receiving fractionated radiotherapy 2Gy per fraction with a total dose of 60Gy scheduled to be delivered in 6 weeks, along with continuous daily infusions of fluorouracil 200 mg/m with one hour infusion of cisplatin 4mg/m before radiotherapy on the same days. However, one of the two patients developed grade IV oesophageal fistula during treatment, which required treatment discontinuation at a dose of 46Gy. The second patient developed grade IV leucopenia [time to reactions onset and outcomes not stated]. Author comment: "Herein, we retrospectively investigated the treatment outcomes of CCRT with the LDFP regimen for stage I-II esophageal cancer patients receiving long-term follow-up." "[T]he toxicities that occurred during and after the treatment period...leukopenia...Grade 4 in one." "One patient developed Grade 4 esophageal fistula during the treatment period and CRT was suspended at the time point when a dose of 46Gy was being administered." Kumabe A, et al. Long-term results of concurrent chemoradiotherapy with daily- low-dose continuous infusion of 5-fluorouracil and cisplatin (LDFP) for Stage I-II esophageal carcinoma. Diseases of the Esophagus 31: dox138, No. 4, 01 Apr 2018. Available from: URL: http://doi.org/10.1093/dote/dox138 - Japan 803323954 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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