Reactions 1704, p100 - 2 Jun 2018
Leucopenia and oesophageal fistula: 2 case reports
In a retrospective study involving 76 patients, two patients
[ages and sexes not stated] were described, who developed
leucopenia or oesophageal fistula during treatment with
fluorouracil [5-fluorouracil] and cisplatin for stage I
squamous cell oesophageal cancer.
The patients with histologically proven stage I
cell carcinoma of the oesophagus, started receiving concurrent
chemoradiotherapy. The patients started receiving
fractionated radiotherapy 2Gy per fraction with a total dose of
60Gy scheduled to be delivered in 6 weeks, along with
continuous daily infusions of fluorouracil 200 mg/m
hour infusion of cisplatin 4mg/m
before radiotherapy on the
same days. However, one of the two patients developed
grade IV oesophageal fistula during treatment, which required
treatment discontinuation at a dose of 46Gy. The second
patient developed grade IV leucopenia [time to reactions onset
and outcomes not stated].
Author comment: "Herein, we retrospectively investigated
the treatment outcomes of CCRT with the LDFP regimen for
stage I-II esophageal cancer patients receiving long-term
follow-up." "[T]he toxicities that occurred during and after the
treatment period...leukopenia...Grade 4 in one." "One patient
developed Grade 4 esophageal fistula during the treatment
period and CRT was suspended at the time point when a
dose of 46Gy was being administered."
Kumabe A, et al. Long-term results of concurrent chemoradiotherapy with daily-
low-dose continuous infusion of 5-fluorouracil and cisplatin (LDFP) for Stage I-II
esophageal carcinoma. Diseases of the Esophagus 31: dox138, No. 4, 01 Apr 2018.
Available from: URL: http://doi.org/10.1093/dote/dox138 - Japan
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved