Cisplatin/fluorouracil

Cisplatin/fluorouracil Reactions 1704, p101 - 2 Jun 2018 Numbness and fatigue: case report In a retrospective study of 17 patients, a 77-year-old woman developed numbness and a 72-year-old woman developed fatigue during treatment with cisplatin and fluorouracil [5-fluorouracil; routes, times to reactions onsets and outcomes not stated]. Patient 2 (from table 1 of the article): A 77-year-old woman, who had stage IV T1N2M1 invasive extra-mammary Paget’s disease with metastases to the para-aortic lymph node, started receiving treatment with low dose of fluorouracil 500 mg/body for seven days per week and cisplatin 5 mg/body for five days per week as continuous administration for three weeks with one week off. Subsequently, she developed grade 2 numbness as a side-effect of the cisplatin and fluorouracil combination therapy. She received 14 cycles of the therapy, which was continuing with a partial response to the underlying disease. Patient 8 (from table 1 of the article): A 72-year-old woman, who had stage IV T3N2M1 invasive extra-mammary Paget’s disease with metastases to the bone, started receiving treatment with low dose of fluorouracil 500 mg/body for seven days per week and cisplatin 5 mg/body for five days per week as continuous administration for three weeks with one week off. Subsequently, she developed grade 2 fatigue as a side- effect of the cisplatin and fluorouracil combination therapy. She received 6 cycles of the therapy, which was eventually discontinued with a partial response to the underlying disease. Author comment: "As non-severe adverse events, there was one case of numbness and one case of fatigue." "The efficacy of combination 5-fluorouracil (500 mg/body, 7 days/week) and cisplatin (5 mg/body 5 days/week) (continued administration for 3 weeks and cessation of the drug for 1 week) for invasive [extramammary Paget’s disease] was retrospectively analysed." Kato H, et al. Efficacy of low-dose 5-fluorouracil/cisplatin therapy for invasive extramammary Paget's disease. Journal of Dermatology 45: 560-563, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/1346-8138.14247 - Japan 803323309 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Cisplatin/fluorouracil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46744-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p101 - 2 Jun 2018 Numbness and fatigue: case report In a retrospective study of 17 patients, a 77-year-old woman developed numbness and a 72-year-old woman developed fatigue during treatment with cisplatin and fluorouracil [5-fluorouracil; routes, times to reactions onsets and outcomes not stated]. Patient 2 (from table 1 of the article): A 77-year-old woman, who had stage IV T1N2M1 invasive extra-mammary Paget’s disease with metastases to the para-aortic lymph node, started receiving treatment with low dose of fluorouracil 500 mg/body for seven days per week and cisplatin 5 mg/body for five days per week as continuous administration for three weeks with one week off. Subsequently, she developed grade 2 numbness as a side-effect of the cisplatin and fluorouracil combination therapy. She received 14 cycles of the therapy, which was continuing with a partial response to the underlying disease. Patient 8 (from table 1 of the article): A 72-year-old woman, who had stage IV T3N2M1 invasive extra-mammary Paget’s disease with metastases to the bone, started receiving treatment with low dose of fluorouracil 500 mg/body for seven days per week and cisplatin 5 mg/body for five days per week as continuous administration for three weeks with one week off. Subsequently, she developed grade 2 fatigue as a side- effect of the cisplatin and fluorouracil combination therapy. She received 6 cycles of the therapy, which was eventually discontinued with a partial response to the underlying disease. Author comment: "As non-severe adverse events, there was one case of numbness and one case of fatigue." "The efficacy of combination 5-fluorouracil (500 mg/body, 7 days/week) and cisplatin (5 mg/body 5 days/week) (continued administration for 3 weeks and cessation of the drug for 1 week) for invasive [extramammary Paget’s disease] was retrospectively analysed." Kato H, et al. Efficacy of low-dose 5-fluorouracil/cisplatin therapy for invasive extramammary Paget's disease. Journal of Dermatology 45: 560-563, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/1346-8138.14247 - Japan 803323309 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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