Ir J Med Sci (2017) 186:785–794 DOI 10.1007/s11845-017-1554-7 ORIGINAL ARTICLE Circulating levels of ﬁbroblast growth factor 21 in early-stage diabetic kidney disease 1 1 1 1 1 • • • • • A. Esteghamati A. Khandan A. Momeni A. Behdadnia A. Ghajar 1 1 1 1 • • • M. S. Nikdad S. Noshad M. Nakhjavani M. Afarideh Received: 23 December 2015 / Accepted: 11 January 2017 / Published online: 8 February 2017 Royal Academy of Medicine in Ireland 2017 Abstract (n = 44) microalbuminuria and their healthy controls Aims/purpose Fibroblast growth factor 21 (FGF21), a (n = 42) were recruited for analysis. Various demographic, hepatoadipokine with pleiotropic metabolic regulatory clinical and biochemical parameters were assessed. actions, is emerging as a novel biomarker of progressive Results Serum FGF21 levels were signiﬁcantly elevated in nephropathy. We sought to evaluate circulating FGF21 and patients with microalbuminuria [median (interquartile its association with clinical and biochemical characteristics range, IQR): 269.50 (188.50) pg/mL] compared to their as well as the urinary albumin excretion (UAE) rates in a normoalbuminuric peers with T2D [median (IQR): 103.50 population of patients with type 2 diabetes (T2D) with or (75.75) pg/mL] and nondiabetic people [median (IQR): without microalbuminuria and
Irish Journal of Medical Science (1971 -) – Springer Journals
Published: Feb 8, 2017
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