Osteoporos Int (2017) 28:2683–2689 DOI 10.1007/s00198-017-4104-2 ORIGINAL ARTICLE Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults 1 1 1,2 1 3 J. Coulson & L. Bagley & Y. Barnouin & S. Bradburn & G. Butler-Browne & 4 3 5 6,7 8 H. Gapeyeva & J.-Y. Hogrel & T. Maden-Wilkinson & A. B. Maier & C. Meskers & 1 9 4 10 11 1 C. Murgatroyd & M. Narici & M. Pääsuke & L. Sassano & S. Sipilä & N. AL-Shanti & 11,12 1 1 L. Stenroth & D. A. Jones & J. S. McPhee Received: 10 January 2017 /Accepted: 23 May 2017 /Published online: 5 June 2017 International Osteoporosis Foundation and National Osteoporosis Foundation 2017 Abstract subjects (69 to 81 years; 52% female) and 171 younger subjects Summary Bone mineral density declines with increasing older (18–30 years; 53% female). age. We examined the levels of circulating factors known to Results WBMD was lower in old than young. Circulating regulate bone metabolism in healthy young and older adults. osteocalcin was lower in old compared with young, while The circulating levels
Osteoporosis International – Springer Journals
Published: Jun 5, 2017
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