Cancer Causes Control (2017) 28:939–946 DOI 10.1007/s10552-017-0917-8 ORIGINAL PAPER Circulating leptin and adiponectin, and breast density in premenopausal Mexican women: the Mexican Teachers’ Cohort 1 1 1 1 2,3 • • • • • L. Dossus S. Rinaldi C. Biessy M. Hernandez M. Lajous 2 2 2 2 2 • • • • • A. Monge E. Ortiz-Panozo E. Yunes R. Lopez-Ridaura G. Torres-Mejı ´a 1,2 I. Romieu Received: 9 February 2017 / Accepted: 21 June 2017 / Published online: 4 July 2017 Springer International Publishing AG 2017 Abstract with percentage MD. After adjustment for BMI, only the Purpose Leptin and adiponectin are produced by the adi- associations between percentage MD and absolute non- pose tissue. Mammographic density (MD) is one of the dense tissue area with leptin remained statistically strongest predictors of breast cancer (BC) and is highly signiﬁcant. inﬂuenced by adiposity. How the interplay between MD, Conclusions Leptin, adiponectin, and their ratio were obesity, and obesity-related biomarkers inﬂuences BC risk, associated with MD; however, only the positive association however, is still unknown, especially in premenopausal with leptin seemed to be independent from overall obesity. women, where adiposity seems to be protective for BC. The aim of the
Cancer Causes & Control – Springer Journals
Published: Jul 4, 2017
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