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Ciprofloxacin/mercaptopurine/methotrexate

Ciprofloxacin/mercaptopurine/methotrexate Reactions 1680, p86 - 2 Dec 2017 X S Ciprofloxacin/mercaptopurine/ methotrexate Sinusoidal obstruction syndrome and portal hypertension: case report A 7-year-old boy developed portal hypertension secondary to sinusoidal obstruction syndrome (SOS) during the concomitant administration of ciprofloxacin and methotrexate. Additionally, he was receiving treatment with mercaptopurine [6-mercaptopurine], which also contributed in the development of SOS [not all routes, dosages and outcomes stated; durations of treatments to reactions onset not stated]. The boy, who was diagnosed with pre-B cell acute lymphoblastic leukaemia, was receiving maintenance chemotherapy as per children’s oncology group protocol AALL0932. He received mercaptopurine 75 mg/m /dose daily and oral methotrexate 20 mg/m /dose weekly along with vincristine and dexamethasone. Thereafter, he developed BK virus infection, which required treatment with ciprofloxacin for 10 days. However, he experienced weight gain, progressive abdominal distension, tender hepatomegaly and jaundice for two weeks. These symptoms led to differential diagnosis of Budd Chiari Syndrome or viral hepatitis or SOS. His laboratory investigations yielded negative results for serum BK virus PCR and negative serology for cytomegalovirus, hepatitis A, B, C and E virus, Ebstein Barr virus. Additionally, methotrexate was detected in examinations seven days even after its last dose. Ultrasound of the right upper http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Ciprofloxacin/mercaptopurine/methotrexate

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Ciprofloxacin/mercaptopurine/methotrexate

Abstract

Reactions 1680, p86 - 2 Dec 2017 X S Ciprofloxacin/mercaptopurine/ methotrexate Sinusoidal obstruction syndrome and portal hypertension: case report A 7-year-old boy developed portal hypertension secondary to sinusoidal obstruction syndrome (SOS) during the concomitant administration of ciprofloxacin and methotrexate. Additionally, he was receiving treatment with mercaptopurine [6-mercaptopurine], which also contributed in the development of SOS [not all routes, dosages and outcomes stated;...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39017-x
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p86 - 2 Dec 2017 X S Ciprofloxacin/mercaptopurine/ methotrexate Sinusoidal obstruction syndrome and portal hypertension: case report A 7-year-old boy developed portal hypertension secondary to sinusoidal obstruction syndrome (SOS) during the concomitant administration of ciprofloxacin and methotrexate. Additionally, he was receiving treatment with mercaptopurine [6-mercaptopurine], which also contributed in the development of SOS [not all routes, dosages and outcomes stated; durations of treatments to reactions onset not stated]. The boy, who was diagnosed with pre-B cell acute lymphoblastic leukaemia, was receiving maintenance chemotherapy as per children’s oncology group protocol AALL0932. He received mercaptopurine 75 mg/m /dose daily and oral methotrexate 20 mg/m /dose weekly along with vincristine and dexamethasone. Thereafter, he developed BK virus infection, which required treatment with ciprofloxacin for 10 days. However, he experienced weight gain, progressive abdominal distension, tender hepatomegaly and jaundice for two weeks. These symptoms led to differential diagnosis of Budd Chiari Syndrome or viral hepatitis or SOS. His laboratory investigations yielded negative results for serum BK virus PCR and negative serology for cytomegalovirus, hepatitis A, B, C and E virus, Ebstein Barr virus. Additionally, methotrexate was detected in examinations seven days even after its last dose. Ultrasound of the right upper

Journal

Reactions Weekly – Springer Journals

Published: Dec 2, 2017

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