Acta Neuropathologica (2018) 135:481–484 https://doi.org/10.1007/s00401-018-1808-0 CORRESPONDENCE cIMPACT‑NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC) 1 2,3,4 5 6 7 David N. Louis · Pieter Wesseling · Werner Paulus · Caterina Giannini · Tracy T. Batchelor · 8 9,10 11 12 13 J. Gregory Cairncross · David Capper · Dominique Figarella‑Branger · M. Beatriz Lopes · Wolfgang Wick · Martin van den Bent Received: 11 January 2018 / Accepted: 15 January 2018 / Published online: 25 January 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Introduction classification and grading challenges. Working Committee 3 addressed questions concerning the use of NOS (Not Oth- cIMPACT-NOW (the Consortium to Inform Molecular and erwise Specified) diagnoses and clarified diagnostic criteria Practical Approaches to CNS Tumor Taxonomy– Not Offi - for two entities. The present correspondence reports the rec- cial WHO) was established to provide a forum for evaluat- ommendations of Working Committee concerning the use of ing and recommending proposed changes to future central NOS diagnoses, introduces the term NEC (Not Elsewhere nervous system (CNS) tumor classifications [ 1, 2]. While it Classified), and clarifies the distinction between NOS and is understood that the major impact on international brain NEC when used for CNS tumor diagnosis. tumor classification comes about through the World Health The 2016
Acta Neuropathologica – Springer Journals
Published: Jan 25, 2018
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