Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management Purpose of Review Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex. Recent Findings Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. Summary In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit. . . . . Keywords Pediatric chronic rhinosinusitis Osteomeatal complex Nasal polyps Treatment of pediatric chronic rhinosinusitis Mucociliary clearance Monoclonal antibodies Introduction purulence or discolored postnasal discharge, or fever) or one major and two minor criteria (halitosis, dental pain, fatigue, Rhinosinusitis is a common disorder involving inflammation cough, ear pain, ear pressure, or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
D.O.I.
10.1007/s11882-018-0792-8
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex. Recent Findings Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. Summary In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit. . . . . Keywords Pediatric chronic rhinosinusitis Osteomeatal complex Nasal polyps Treatment of pediatric chronic rhinosinusitis Mucociliary clearance Monoclonal antibodies Introduction purulence or discolored postnasal discharge, or fever) or one major and two minor criteria (halitosis, dental pain, fatigue, Rhinosinusitis is a common disorder involving inflammation cough, ear pain, ear pressure, or

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: May 29, 2018

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