Chromosome scaffold and structural integrity of mitotic chromosomes

Chromosome scaffold and structural integrity of mitotic chromosomes Chromosome scaffold represents a continuous protein substructure revealed in isolated metaphase chromosomes after harsh extraction. According to postulates of the widespread radial loop model the scaffold plays an important role in the formation and maintenance of structural integrity of the mitotic chromosomes. Here, the data concerning the structure and major components of the chromosome scaffold are presented. The experiments suggesting that the scaffold represents a system of discrete linker proteins and the data about high mobility of scaffolding proteins are discussed. Furthermore, the data about higher-level chromatin structures (elementary chromonema and 200–250 nm fibers) and behavior of scaffolding proteins are compared. The results presented agree with the idea that at the present stage it is possible to discriminate chromatin complexes, whose structural integrity is not maintained by the chromosome scaffold. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Chromosome scaffold and structural integrity of mitotic chromosomes

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Publisher
Nauka/Interperiodica
Copyright
Copyright © 2006 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360406060014
Publisher site
See Article on Publisher Site

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