Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin

Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin The effect of mutation for gene Merlin on chromosome disjunction in Drosophila during meiosis was genetically studied. Chromosome nondisjunction was not registered in females heterozygous for this mutation and containing structurally normal X chromosomes. In cases when these females additionally contained inversion in one of chromosomes X, a tendency toward the appearance of nondisjunction events was observed in individuals containing mutation in the heterozygote. The genetic construct was obtained allowing the overexpression of protein corresponding to a sterile allele Mer 3 in the germ cell line. This construct relieves the lethal effect of Mer 4 mutation. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis. Russian Journal of Genetics Springer Journals

Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin

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SP MAIK Nauka/Interperiodica
Copyright © 2008 by Pleiades Publishing, Ltd.
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
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