Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin

Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin The effect of mutation for gene Merlin on chromosome disjunction in Drosophila during meiosis was genetically studied. Chromosome nondisjunction was not registered in females heterozygous for this mutation and containing structurally normal X chromosomes. In cases when these females additionally contained inversion in one of chromosomes X, a tendency toward the appearance of nondisjunction events was observed in individuals containing mutation in the heterozygote. The genetic construct was obtained allowing the overexpression of protein corresponding to a sterile allele Mer 3 in the germ cell line. This construct relieves the lethal effect of Mer 4 mutation. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Chromosome nondisjunction in Drosophila strains mutant for tumor suppressor Merlin

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2008 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795408030186
Publisher site
See Article on Publisher Site

Abstract

The effect of mutation for gene Merlin on chromosome disjunction in Drosophila during meiosis was genetically studied. Chromosome nondisjunction was not registered in females heterozygous for this mutation and containing structurally normal X chromosomes. In cases when these females additionally contained inversion in one of chromosomes X, a tendency toward the appearance of nondisjunction events was observed in individuals containing mutation in the heterozygote. The genetic construct was obtained allowing the overexpression of protein corresponding to a sterile allele Mer 3 in the germ cell line. This construct relieves the lethal effect of Mer 4 mutation. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jan 19, 2011

References

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