Brief Data Report 266 Mammalian Genome 9, [2,6]. Two other homologs with about 80% amino acid identity to Chromosomal localization of three human these pancreatic ribonucleases have been found in different bovine genes encoding members of the TGF-(3 tissues: a seminal ribonuclease, which, unlike all other enzymes of the mammalian ribonuclease superfamily, is a homodimer whose superfamily of type I serine/threonine chains are linked by two disulfide bonds ; and a brain ribo- kinase receptors nuclease, which, unlike the pancreatic and seminal homologs, has a carboxy-terminal extension with 0-linked oligosaccharide chains E. Roijer, l K. Miyazono, 2 A. -K. Astrom, 1 . The genes encoding these enzymes were cloned from cattle [6, A. Geurts van Kessel, 3 P. ten Dijke, 4 G. Stenman' and unpublished]. These clones were used for cloning the sheep and giraffe genes, which were then sequenced . The seminal 'Laboratory of Cancer Genetics, Department of Pathology, Goteborg ribonuclease appears to be a pseudogene in all ruminant species University, Sahlgrenska University Hospital, SE-413 45 examined so far, except cattle and water buffalo [6,7]. Phyloge- Goteborg, Sweden netic analysis suggests that these three homologs have arisen by Department of Biochemistry, The Cancer Institute, Tokyo, Japanese gene duplication
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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