Chromosomal localization of three human genes encoding members of the TGF-β superfamily of type I serine/threonine kinase receptors

Chromosomal localization of three human genes encoding members of the TGF-β superfamily of type... Brief Data Report 266 Mammalian Genome 9, [2,6]. Two other homologs with about 80% amino acid identity to Chromosomal localization of three human these pancreatic ribonucleases have been found in different bovine genes encoding members of the TGF-(3 tissues: a seminal ribonuclease, which, unlike all other enzymes of the mammalian ribonuclease superfamily, is a homodimer whose superfamily of type I serine/threonine chains are linked by two disulfide bonds [6]; and a brain ribo- kinase receptors nuclease, which, unlike the pancreatic and seminal homologs, has a carboxy-terminal extension with 0-linked oligosaccharide chains E. Roijer, l K. Miyazono, 2 A. -K. Astrom, 1 [6]. The genes encoding these enzymes were cloned from cattle [6, A. Geurts van Kessel, 3 P. ten Dijke, 4 G. Stenman' and unpublished]. These clones were used for cloning the sheep and giraffe genes, which were then sequenced [2]. The seminal 'Laboratory of Cancer Genetics, Department of Pathology, Goteborg ribonuclease appears to be a pseudogene in all ruminant species University, Sahlgrenska University Hospital, SE-413 45 examined so far, except cattle and water buffalo [6,7]. Phyloge- Goteborg, Sweden netic analysis suggests that these three homologs have arisen by Department of Biochemistry, The Cancer Institute, Tokyo, Japanese gene duplication http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Chromosomal localization of three human genes encoding members of the TGF-β superfamily of type I serine/threonine kinase receptors

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900745
Publisher site
See Article on Publisher Site

Abstract

Brief Data Report 266 Mammalian Genome 9, [2,6]. Two other homologs with about 80% amino acid identity to Chromosomal localization of three human these pancreatic ribonucleases have been found in different bovine genes encoding members of the TGF-(3 tissues: a seminal ribonuclease, which, unlike all other enzymes of the mammalian ribonuclease superfamily, is a homodimer whose superfamily of type I serine/threonine chains are linked by two disulfide bonds [6]; and a brain ribo- kinase receptors nuclease, which, unlike the pancreatic and seminal homologs, has a carboxy-terminal extension with 0-linked oligosaccharide chains E. Roijer, l K. Miyazono, 2 A. -K. Astrom, 1 [6]. The genes encoding these enzymes were cloned from cattle [6, A. Geurts van Kessel, 3 P. ten Dijke, 4 G. Stenman' and unpublished]. These clones were used for cloning the sheep and giraffe genes, which were then sequenced [2]. The seminal 'Laboratory of Cancer Genetics, Department of Pathology, Goteborg ribonuclease appears to be a pseudogene in all ruminant species University, Sahlgrenska University Hospital, SE-413 45 examined so far, except cattle and water buffalo [6,7]. Phyloge- Goteborg, Sweden netic analysis suggests that these three homologs have arisen by Department of Biochemistry, The Cancer Institute, Tokyo, Japanese gene duplication

Journal

Mammalian GenomeSpringer Journals

Published: Mar 21, 2009

References

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