Mammahan Genome 8, 141-142 (1997). ~enome 9 Sprmger-Verlag New York lnc 1997 Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases Marc K. Saba-EI-Leil, 1 Danielle Malo, z Sylvain Meloche 1 'Centre de Recherche, HStel-Dieu de Montr6al, 3850 St. Urbain Street, and Department of Pharmacology, University of Montreal, Montreal, Quebec, Canada, H2W 1T8 The Montreal General Hospital Research Institute, Montreal, Quebec, Canada, H3G 1A4 Received: 22 August 1996 / Accepted 25 September 1996 Mitogen-activated protein (MAP) kinases form a conserved family C57BL/6J and Mus spretus parental strain was digested with sev- of serine/threonine kinases that are activated in response to a wide eral restriction enzymes and analyzed by Southern blot hybridiza- variety of extracellular signals. In vertebrate cells, three distinct tion for informative restriction fragment length polymorphisms subfamilies of MAP kinases have been identified and character- (RFLPs) with the 1.5-kb XbaI fragment of the ERK2 gene. The ized: the extracellular-signal regulated kinases (ERKs), the Jun MspI digestion identified polymorphic fragments with this probe: N-terminal kinases/stress-activated protein kinases, and p38 (Cano 7.0 kb for C57BL/6J and 3.7 kb for Mus spretus (data not shown). and Mahadevan 1995; Cobb and Goldsmith 1995). The ERK sub-
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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