Short Communications Incorporating Mouse Genome Mammalian Genome 10, 397–398 (1999). © Springer-Verlag New York Inc. 1999 Chromosomal localization of the Huntingtin Associated Protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping 1, 1, 2 2 2 2 2 1 J. Nasir, * A. Maclean, * S. Engelender, K. Duan, R.L. Margolis, J.J. Kleiderlein, C.A. Ross, M.R. Hayden 1 th Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, 980 West 28 Avenue, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada Laboratory of Molecular Neurobiology, Departments of Psychiatry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA Received: 12 August 1998 / Accepted: 4 December 1998 The Huntingtin Associated protein, HAP-1, is predominantly ex- pressed in the brain, where it interacts with huntingtin, the protein product of the Huntington’s disease gene (Li et al. 1995). Its pre- dominantly neuronal expression pattern in rat, mouse, human, and primates, together with its increased affinity for mutant huntingtin suggests that HAP-1 may play an important role in the pathogen- esis of Huntington’s disease (Li et al. 1995, 1996, 1998; Page et al. 1998). In the mouse, HAP-1 is also expressed in the testis
Mammalian Genome – Springer Journals
Published: Apr 1, 1999
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