Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas

Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas Mammalian Genome 9, 84-85 (1998). Mammalian Genome Incorporating Mo G,.—, © Springer-Verlag New York Inc. 1998 Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas Lakshmi Rajan, 1 Christine A. Kozak, 2 Jaquelin P. Dudley' 'Department of Microbiology, University of Texas at Austin, Austin, Texas 78712, USA 2Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA Received: 8 June 1997 / Accepted: 26 August 1997 Mouse mammary tumor virus (MMTV) causes mammary carci- ing to Green (1981), and loci were ordered by minimizing the nomas and T-cell tumors in mice (Dudley and Risser 1984). Unlike number of recombinants using the program LOCUS (Krebsbach et acutely oncogenic retroviruses, the MMTV genome does not carry al. 1996). an oncogene, but exerts its oncogenic effects by the transcriptional Southern blotting identified unique fragments in parental activation of cellular proto-oncogenes located in the vicinity of DNAs with each of the three novel Pad probes (Table 1). The proviral integration sites. Activation of transcription at nine dif- Pad4 locus was mapped using the p2B3 probe, a 0.6-kb EcoRI- ferent loci—namely, Wnt1, Fgf3, Notch4, Wnt3, Cyp19, Fgf4, Pstl fragment derived from sequences flanking an acquired Fg18, Int6, and Wnt10b—has http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900687
Publisher site
See Article on Publisher Site

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