Mammalian Genome 9, 84-85 (1998). Mammalian Genome Incorporating Mo G,.—, © Springer-Verlag New York Inc. 1998 Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas Lakshmi Rajan, 1 Christine A. Kozak, 2 Jaquelin P. Dudley' 'Department of Microbiology, University of Texas at Austin, Austin, Texas 78712, USA 2Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA Received: 8 June 1997 / Accepted: 26 August 1997 Mouse mammary tumor virus (MMTV) causes mammary carci- ing to Green (1981), and loci were ordered by minimizing the nomas and T-cell tumors in mice (Dudley and Risser 1984). Unlike number of recombinants using the program LOCUS (Krebsbach et acutely oncogenic retroviruses, the MMTV genome does not carry al. 1996). an oncogene, but exerts its oncogenic effects by the transcriptional Southern blotting identified unique fragments in parental activation of cellular proto-oncogenes located in the vicinity of DNAs with each of the three novel Pad probes (Table 1). The proviral integration sites. Activation of transcription at nine dif- Pad4 locus was mapped using the p2B3 probe, a 0.6-kb EcoRI- ferent loci—namely, Wnt1, Fgf3, Notch4, Wnt3, Cyp19, Fgf4, Pstl fragment derived from sequences flanking an acquired Fg18, Int6, and Wnt10b—has
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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