Chlorpromazine

Chlorpromazine Reactions 1704, p97 - 2 Jun 2018 Blindness, decreased visual acuity and transient palpebral ptosis: 3 case reports In a longitudinal, retrospective study of 33 patients, three patients [ages and sexes not stated] were described, who developed blindness (1 patient), decreased visual acuity (1 patients) and transient palpebral ptosis (1 patient) following treatment with chlorpromazine [chlorpromazine hydrochloride]. All patients, who had blind painful eye or residual vision painful eye underwent retrobulbular chlorpromazine application technique. Initially, all patients received a retrobulbar injection of lidocaine as anaesthetic agent. After that, a 3cc syringe was attached to the same needle, proceeding to the application of chlorpromazine 2mL (25mg) on the retrobulbar level for one minute. After completion, eyeball compression was used for 5min. Out of these three patients, two patient, who had a residual vision prior to the application of chlorpromazine, went from projection of light to no light perception and counting fingers to seeing masses, respectively. The third patient developed palpebral ptosis, which remained unchanged until the last follow-up [durations of treatments to reactions onset not stated; not all outcomes stated]. Author comment: [O]ne eye went from [projection of light ] to [no light perception]". "[O]ne eye went from counting fingers to seeing masses." "[M]ild complications in 5 patients that included transient palpebral ptosis . . . one case remained unchanged until the last follow-up." Ortiz A, et al. Retrobulbar chlorpromazine in management of painful eye in blind or low vision patients. Archivos de la Sociedad Espanola de Oftalmologia 92: 154-159, No. 4, Apr 2017. Available from: URL: http://doi.org/10.1016/ j.oftal.2016.10.022 [Spanish; summarised from a translation] - Colombia 803323222 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Chlorpromazine

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46740-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p97 - 2 Jun 2018 Blindness, decreased visual acuity and transient palpebral ptosis: 3 case reports In a longitudinal, retrospective study of 33 patients, three patients [ages and sexes not stated] were described, who developed blindness (1 patient), decreased visual acuity (1 patients) and transient palpebral ptosis (1 patient) following treatment with chlorpromazine [chlorpromazine hydrochloride]. All patients, who had blind painful eye or residual vision painful eye underwent retrobulbular chlorpromazine application technique. Initially, all patients received a retrobulbar injection of lidocaine as anaesthetic agent. After that, a 3cc syringe was attached to the same needle, proceeding to the application of chlorpromazine 2mL (25mg) on the retrobulbar level for one minute. After completion, eyeball compression was used for 5min. Out of these three patients, two patient, who had a residual vision prior to the application of chlorpromazine, went from projection of light to no light perception and counting fingers to seeing masses, respectively. The third patient developed palpebral ptosis, which remained unchanged until the last follow-up [durations of treatments to reactions onset not stated; not all outcomes stated]. Author comment: [O]ne eye went from [projection of light ] to [no light perception]". "[O]ne eye went from counting fingers to seeing masses." "[M]ild complications in 5 patients that included transient palpebral ptosis . . . one case remained unchanged until the last follow-up." Ortiz A, et al. Retrobulbar chlorpromazine in management of painful eye in blind or low vision patients. Archivos de la Sociedad Espanola de Oftalmologia 92: 154-159, No. 4, Apr 2017. Available from: URL: http://doi.org/10.1016/ j.oftal.2016.10.022 [Spanish; summarised from a translation] - Colombia 803323222 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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