Reactions 1704, p93 - 2 Jun 2018 Infusion related reaction and cytopenia: 2 case reports In a retrospective review of nine patients, two elderly patients [exact ages and sexes not stated] were described, out of whom, one patient developed infusion related reaction and the other patient developed cytopenia during treatment with obinutuzumab and chlorambucil for chronic lymphatic leukaemia [dosages and outcome not stated]. Case 1: The patient, who had an untreated chronic lymphatic leukaemia, started receiving treatment with an infusion of obinutuzumab and chlorambucil. At the time of treatment initiation, the patient had lymphocyte count in excess of 100. With the first infusion of obinutuzumab and chlorambucil, the patient developed grade III infusion related reaction. Subsequently, infusion related reaction resolved and did not recur during further treatment. Case 2: The patient, who had an untreated chronic lymphatic leukaemia, started receiving treatment with an infusion of obinutuzumab and chlorambucil. Subsequently, the patient developed treatment-related grade III/IV cytopenias after every cycle. Therefore, treatment with obinutuzumab and chlorambucil was discontinued after three cycles. Author comment: "All patients initiated on Obinutuzumab and Chlorambucil were included." "Objectives: To assess safety including infusion related reactions and cytopenias and response to treatment." "Out of 9 patients, 7 patients had grade 1–2 infusion reactions, 1 had grade 3 reaction . . . 1 patient had to discontinue after 3 cycles for grade 3/4 cytopenias after every cycle." Owen S, et al. Single hospital retrospective review of obinutuzumab and chlorambucil combination therapy in patients with untreated chronic lymphatic leukaemia in a district general hospital (DGH). British Journal of Haematology 181 (Suppl. 1): 182 abstr. BSH18-EP-048, Apr 2018. Available from: URL: http:// doi.org/10.1111/bjh.15226 [abstract] - United Kingdom 803323318 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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