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D. Coutandin, C. Osterburg, R. Srivastav, M. Sumyk, S. Kehrloesser, J. Gebel, M. Tuppi, Jens Hannewald, B. Schäfer, E. Salah, S. Mathea, U. Müller-Kuller, J. Doutch, M. Grez, S. Knapp, V. Dötsch (2016)
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular leveleLife, 5
S. Gonfloni, L. Tella, S. Caldarola, S. Cannata, F. Klinger, C. Bartolomeo, Maurizio Mattei, E. Candi, M. Felici, G. Melino, G. Cesareni (2009)
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced deathNature Medicine, 15
V. Rossi, M. Lispi, S. Longobardi, Maurizio Mattei, F. Rella, A. Salustri, M. Felici, F. Klinger (2016)
LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouseCell Death and Differentiation, 24
J. Kerr, K. Hutt, Michele Cook, T. Speed, A. Strasser, J. Findlay, C. Scott (2012)
Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinibNature Medicine, 18
Ewelina Bolcun-Filas, Vera Rinaldi, M. White, J. Schimenti (2014)
Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint PathwayScience, 343
E. Suh, A. Yang, A. Kettenbach, Casimir Bamberger, Ala Michaelis, Zhou Zhu, J. Elvin, R. Bronson, C. Crum, F. McKeon (2006)
p63 protects the female germ line during meiotic arrestNature, 444
R. Johnston, W. Wallace (2009)
Normal ovarian function and assessment of ovarian reserve in the survivor of childhood cancerPediatric Blood & Cancer, 53
M. Vos, J. Smitz, T. Woodruff (2014)
Fertility preservation in women with cancerThe Lancet, 384
G. Deutsch, E. Zielonka, D. Coutandin, Tobias Weber, B. Schäfer, Jens Hannewald, L. Luh, Florian Durst, M. Ibrahim, J. Hoffmann, F. Niesen, Aycan Sentürk, H. Kunkel, B. Brutschy, E. Schleiff, S. Knapp, A. Acker-Palmer, M. Grez, F. McKeon, V. Dötsch (2011)
DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to TetramerCell, 144
Dal-Ah Kim, E. Suh (2014)
Defying DNA Double-Strand Break-Induced Death during Prophase I Meiosis by Temporal TAp63α Phosphorylation Regulation in Developing Mouse OocytesMolecular and Cellular Biology, 34
L. Luh, S. Kehrloesser, G. Deutsch, J. Gebel, D. Coutandin, B. Schäfer, M. Agostini, G. Melino, V. Dötsch (2013)
Analysis of the oligomeric state and transactivation potential of TAp73αCell Death and Differentiation, 20
M. Tuppi, S. Kehrloesser, D. Coutandin, V. Rossi, L. Luh, A. Strubel, Katharina Hötte, Meike Hoffmeister, B. Schäfer, Tiago Oliveira, F. Greten, E. Stelzer, S. Knapp, M. Felici, C. Behrends, F. Klinger, V. Dötsch (2018)
Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63Nature Structural & Molecular Biology, 25
I. Amelio, F. Grespi, M. Annicchiarico-Petruzzelli, G. Melino (2012)
p63 the guardian of human reproductionCell Cycle, 11
J. Gebel, M. Tuppi, K. Krauskopf, D. Coutandin, Susanne Pitzius, S. Kehrloesser, C. Osterburg, V. Dötsch (2017)
Control mechanisms in germ cells mediated by p53 family proteinsJournal of Cell Science, 130
J. Kerr, K. Hutt, Ewa Michalak, Michele Cook, C. Vandenberg, S. Liew, P. Bouillet, A. Mills, C. Scott, J. Findlay, A. Strasser (2012)
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.Molecular cell, 48 3
Cell Death & Differentiation (2018) 25:1007–1009 https://doi.org/10.1038/s41418-018-0107-6 COMMENT 1,2 1 1 ● ● Sebastian Kehrloesser Marcel Tuppi Volker Dötsch Published online: 17 April 2018 © ADMC Associazione Differenziamento e Morte Cellulare 2018 TAp63α has been identified as the major quality control the active tetramer with a 20-fold higher DNA binding factor in the female germline more than a decade ago by the affinity [7]. Activated TAp63α then orchestrates the group of Frank McKeon. DNA damage in primary oocytes, induction of apoptosis by driving transcription of genes within primordial follicles, that constitute the ovarian coding for the BH3 only proteins PUMA and NOXA [8]. reserve in women, results in the phosphorylation-dependent Although several kinases and phosphorylation sites have activation of p63 that in turn induces apoptosis of the been suggested, the exact activation mechanism for affected oocytes [1]. Although this mechanism is crucial to TAp63α remained enigmatic and in part controversially ensure oocyte quality throughout the reproductive lifespan, discussed [9, 10]. Although CHK2 has been identified as a female cancer patients treated with DNA damaging che- kinase essential for activation of TAp63α [11], we report motherapy or pelvic radiotherapy frequently suffer from now that phosphorylation at S582 is essential but
Cell Death & Differentiation – Springer Journals
Published: Apr 17, 2018
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