& Nourallah Hazeri firstname.lastname@example.org Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran 123 8070 S. Zhaleh et al. Keywords Chitosan 1,4-Dihydropyridine Green synthesis Solvent-free condition Reusability Introduction Recently, multicomponent reactions (MCRs) have been found to be a powerful and versatile tool in the synthesis of many chemical compounds in biological and pharmacological scopes. The great capability of these reactions is to combine two or more components in a single step, without the isolation of any intermediates, to synthesize complex and substantial substances with high efﬁciency, simplicity, time saving and atom economy [1–5]. Nowadays, all over the world, green chemistry has become a concern for organic chemists in order to provide important biological and pharmaceutical compounds in a safe and eco-friendly manner to minimize environmentally pollutants as well as destructive consequences on the human body [6, 7]. Hence, in response to anxieties about environmental threats, organic chemists merge multicomponent reactions into green chemistry [8–11]. From this viewpoint, those reactions are more suit- able which are operated without solvents or with non-hazardous solvents. Now, solvent-free multicomponent reactions have modernized conventional procedures via increasing yield, operational simplicity, cost saving and decreasing reaction
Research on Chemical Intermediates – Springer Journals
Published: May 24, 2016
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