Acta Neuropathol (2017) 134:329–330 DOI 10.1007/s00401-017-1750-6 EDITORIAL Childhood white matter disorders: much more than just diseases of myelin 1 1 Marianna Bugiani · Marjo S. van der Knaap Published online: 18 July 2017 © Springer-Verlag GmbH Germany 2017 Childhood white matter disorders and their sequelae consti- the quality of assistance to the preterm child, white mat- tute a major clinical problem associated with considerable ter injury with limited necrosis has largely replaced morbidity and mortality. The genetic forms occur in at least the cystic necrotic periventricular leukomalacia. In his 1:7500 live births, while the overall incidence of acquired exhaustive piece, Back describes the selective maturation- white matter afflictions is not known, comprising amongst dependant vulnerability of late oligodendrocyte progeni- others congenital infections, perinatal damage, and inflam - tors (pre-oligodendrocytes) to oxidative stress induced by matory disorders. The emotional and economic burdens for hypoxia–ischemia or maternal–foetal infection. Pre-oligo- patients, families, and society are enormous. Understand- dendrocytes are pre-myelinating cells still able to divide, ing the pathophysiology of childhood white matter disor- but unable to migrate. They abundantly populate the brain ders is thus necessary to find new openings for treatment white matter between 23 and 32 week post-conception, the and, if possible, cure. This issue of Acta
Acta Neuropathologica – Springer Journals
Published: Jul 18, 2017
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