Chemical Constituents of Viburnum odoratissimum and Their Cytotoxic Activities

Chemical Constituents of Viburnum odoratissimum and Their Cytotoxic Activities DOI 10.1007/s10600-018-2422-z Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 CHEMICAL CONSTITUENTS OF Viburnum odoratissimum AND THEIR CYTOTOXIC ACTIVITIES 1 2 Yi-Chao Ge, Hai-Jiang Zhang, 1 1* Jin-Xiu Lei, and Kui-Wu Wang The genus Viburnum, distributed from South America to Southeast Asia, is the second large genus of Caprifoliaceae. There are about 240 species all over the world and about 80 species in China. Forty-three of them are used as folk medicine in China for their biological properties, such as antibacterial, anti-inflammatory, antitussive, and antinociceptive, being traditionally used for the treatment of menstrual, stomach, and kidney cramps [1, 2]. In the course of our investigation on the chemical constituents of Viburnum odoratissimum Ker Gawl. var. awabuki and other traditional Chinese medicines [3–7], 14 compounds were obtained and identified as -amyrin (1), -amyrin (2), stigmasta-4-en-3-one (3), ergosta-4,6,8(14),22-tetraen-3-one (4), olean-12-en-3-one (5), lupeol (6), 3-hydroxyolean-12-en-1-one (7), 3-acetoxyolean-12-en-28-ol (8), 3-acetoxyolean-12-en-28-oic acid (9), 3,28-dihydroxyolean-12-ene (10), 3,28-dihydroxyurs-12-ene (11), 28-hydroxyolean-12-en-3-one (12), trans-phytol (13), and betulin (14). Compounds 3–14 were isolated from this plant for the first time. Plant Material. The stalks of V. odoratissimum were collected in September 2009 in Huangshan, Anhui, China, and identified by Prof. Bin Wu (Ocean College, Zhejiang University, Hangzhou, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Natural Compounds Springer Journals

Chemical Constituents of Viburnum odoratissimum and Their Cytotoxic Activities

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Pharmacy; Pharmacy; Organic Chemistry; Plant Sciences
ISSN
0009-3130
eISSN
1573-8388
D.O.I.
10.1007/s10600-018-2422-z
Publisher site
See Article on Publisher Site

Abstract

DOI 10.1007/s10600-018-2422-z Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 CHEMICAL CONSTITUENTS OF Viburnum odoratissimum AND THEIR CYTOTOXIC ACTIVITIES 1 2 Yi-Chao Ge, Hai-Jiang Zhang, 1 1* Jin-Xiu Lei, and Kui-Wu Wang The genus Viburnum, distributed from South America to Southeast Asia, is the second large genus of Caprifoliaceae. There are about 240 species all over the world and about 80 species in China. Forty-three of them are used as folk medicine in China for their biological properties, such as antibacterial, anti-inflammatory, antitussive, and antinociceptive, being traditionally used for the treatment of menstrual, stomach, and kidney cramps [1, 2]. In the course of our investigation on the chemical constituents of Viburnum odoratissimum Ker Gawl. var. awabuki and other traditional Chinese medicines [3–7], 14 compounds were obtained and identified as -amyrin (1), -amyrin (2), stigmasta-4-en-3-one (3), ergosta-4,6,8(14),22-tetraen-3-one (4), olean-12-en-3-one (5), lupeol (6), 3-hydroxyolean-12-en-1-one (7), 3-acetoxyolean-12-en-28-ol (8), 3-acetoxyolean-12-en-28-oic acid (9), 3,28-dihydroxyolean-12-ene (10), 3,28-dihydroxyurs-12-ene (11), 28-hydroxyolean-12-en-3-one (12), trans-phytol (13), and betulin (14). Compounds 3–14 were isolated from this plant for the first time. Plant Material. The stalks of V. odoratissimum were collected in September 2009 in Huangshan, Anhui, China, and identified by Prof. Bin Wu (Ocean College, Zhejiang University, Hangzhou,

Journal

Chemistry of Natural CompoundsSpringer Journals

Published: Jun 7, 2018

References

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