DOI 10.1007/s10600-018-2422-z Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 CHEMICAL CONSTITUENTS OF Viburnum odoratissimum AND THEIR CYTOTOXIC ACTIVITIES 1 2 Yi-Chao Ge, Hai-Jiang Zhang, 1 1* Jin-Xiu Lei, and Kui-Wu Wang The genus Viburnum, distributed from South America to Southeast Asia, is the second large genus of Caprifoliaceae. There are about 240 species all over the world and about 80 species in China. Forty-three of them are used as folk medicine in China for their biological properties, such as antibacterial, anti-inflammatory, antitussive, and antinociceptive, being traditionally used for the treatment of menstrual, stomach, and kidney cramps [1, 2]. In the course of our investigation on the chemical constituents of Viburnum odoratissimum Ker Gawl. var. awabuki and other traditional Chinese medicines [3–7], 14 compounds were obtained and identified as -amyrin (1), -amyrin (2), stigmasta-4-en-3-one (3), ergosta-4,6,8(14),22-tetraen-3-one (4), olean-12-en-3-one (5), lupeol (6), 3-hydroxyolean-12-en-1-one (7), 3-acetoxyolean-12-en-28-ol (8), 3-acetoxyolean-12-en-28-oic acid (9), 3,28-dihydroxyolean-12-ene (10), 3,28-dihydroxyurs-12-ene (11), 28-hydroxyolean-12-en-3-one (12), trans-phytol (13), and betulin (14). Compounds 3–14 were isolated from this plant for the first time. Plant Material. The stalks of V. odoratissimum were collected in September 2009 in Huangshan, Anhui, China, and identified by Prof. Bin Wu (Ocean College, Zhejiang University, Hangzhou,
Chemistry of Natural Compounds – Springer Journals
Published: Jun 7, 2018
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