Investigation of the ethyl acetate-soluble layer from the liquid fermentation of Phomopsis asparagi, an endophytic fungus isolated from the Taiwanese endemic plant of Peperomia sui T.T. Lin & S.Y. Lu, led to the isolation of a new cytochalasin, phomocytochalasin A (1), and one benzenoid, phomoaspardiol (2), which was isolated from nature for the first time, along with eight known compounds including two cytochalasins, four benzenoids, one chromone, and one steroid. The structures of the isolates were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques, as well as by comparison with literature reports. Among the isolates, cytochalasin J showed androgen receptor (AR) antagonism with the IC50 value of 6.20 μM.
Chemistry of Natural Compounds – Springer Journals
Published: Jun 7, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud