Mammalian Genome 13, 117–119 (2002). DOI: 10.1007/s00335-001-3042-6 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2002 CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases Eugene F. Schuster, Reinhard Sto ¨ ger th Division of Medical and Molecular Genetics, Guy’s, King’s and St. Thomas’ School of Medicine, King’s College, 8 Floor, Guy’s Tower, Guy’s Hospital, London, SE1 9RT, UK Received: 18 May 2001 / Accepted: 16 October 2001 Chromosomal DNA of eukaryotic cells is functionally organized tion of the cloned cDNA to a human multiple tissue expression by complex formation with nuclear proteins in chromatin. Mul- array filter (Clontech) indicates ubiquitous and invariable, low- tisubunit–protein complexes remodel the chromatin structure and level expression in all normal tissues (data not shown). Ubiquitous thereby establish and maintain cell type-specific gene expression expression and presence of a CpG island at the 58 end are sugges- patterns (reviewed by Aalfs and Kingston 2000). Core components tive of a gene with housekeeping functions (Bird 1986). of known remodeling complexes are DNA and nucleosome- Alignment of the cDNA sequence to genomic sequence stimulated ATPases/helicases, which are characterized by a highly (BLAST algorithm) revealed that this new SWI2/SNF2-like gene conserved SWI2/SNF2-like catalytic domain. is composed of 37
Mammalian Genome – Springer Journals
Published: Feb 15, 2014
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