Characterization of the murine TIGR/myocilin gene

Characterization of the murine TIGR/myocilin gene Mammalian Genome 9, 673–675 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Hadi Abderrahim, Virna L. Jaramillo-Babb, Zhaohui Zhou, Douglas Vollrath Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120, USA Received: 9 January 1998 / Accepted: 10 April 1998 Glaucoma is the second leading cause of vision loss worldwide (Quigley 1996). Open-angle glaucoma is characterized by a pro- gressive loss of peripheral vision with accompanying atrophy of the optic nerve and changes in the appearance of the optic disc. Glaucoma frequently occurs in the context of increased pressure of the aqueous humor, the fluid that circulates through the anterior chamber of the eye. The mechanisms that lead to glaucoma are ill-defined, but many studies have suggested that defects in aque- ous humor outflow, particularly through a structure known as the trabecular meshwork (TM), are responsible for the elevation of intraocular pressure that is associated with a majority of cases of open-angle glaucoma (Rohen 1983). There is a genetic predisposition to primary open-angle glau- coma, illustrated by a disease prevalence of 6% among first degree relatives of affected individuals (Miller and Paterson 1962), com- pared with a prevalence in the general population of less than Mammalian Genome Springer Journals

Characterization of the murine TIGR/myocilin gene

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Copyright © 1998 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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