Characterization of the mouse sialoadhesin gene, Sn

Characterization of the mouse sialoadhesin gene, Sn Mammalian Genome 8,934--937 (1997). 9 Spnnger-Verlag New York Inc. 1997 Stuart Mucklow, L2 Siamon Gordon, 2 Paul R. Crocker I lImperial Cancer Research Fund Molecular Haemopoiesis Laboratory, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, Oxford OX3 9DS, UK 2The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK Received: 20 June 1997 / Accepted: 23 July 1997 Sialoadhesin (Crocker et ~. 1994) is an immunoglobulin super- sociated-glycoprotein (MAG), and Schwann Cell myelin protein family (IgSF; Williams and Barclay 1988) molecule expressed at (SMP). high levels by certain subpopulations of tissue macrophages The sialoadhesin gene, Sn, was previously mapped to the distal (Crocker and Gordon 1989) and is involved in sialic acid- region of mouse Chromosome (Chr) 2 (Mucklow et al. 1995). Here dependent interactions with ligands expressed by other leukocytes we describe the exon organization of Sn and report the detailed (Crocker et al. 1995). This type-I transmembrane protein is an characterization of the coding region of this gene, determined from unusual member of the IgSF in a number of respects (Crocker et al. analyses of two KEMBL3 clones spanning the 5' region of the 1994): the extracellular domain Mammalian Genome Springer Journals

Characterization of the mouse sialoadhesin gene, Sn

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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