Ir J Med Sci (2017) 186:659–669 DOI 10.1007/s11845-016-1511-x O R I G IN AL ARTI CL E Characterization of patients with diabetic foot disease presenting to an Irish Podiatry Centre: proﬁling suitability for entry to a clinical trial of advanced wound therapeutics 1,2 1 1 2,3 • • • A. M. Mahon C. MacGilchrist C. McIntosh T. O’Brien Received: 13 January 2016 / Accepted: 1 October 2016 / Published online: 11 October 2016 Royal Academy of Medicine in Ireland 2016 Abstract ischaemia (P = 0.015). The eligibility criteria were mod- Background Diabetes mellitus, coined the ‘Black Death of elled after those proposed by the EU consortium project the Twenty-First Century’, is associated with complica- REDDSTAR. In this Irish population, these criteria limit tions, including foot ulceration with potential loss of limb. eligibility to 1.4 %. There is a need for development of new wound therapies Conclusions This research found an eligibility criterion of through completion of robust clinical trials. wound area 2–10 cm for enrolment in a clinical trial of Aims To proﬁle demographics and wound characteristics mesenchymal stromal cell therapy too restrictive. Exten- of an Irish cohort with diabetes, forecast eligibility for sion of wound area to 1–10
Irish Journal of Medical Science (1971 -) – Springer Journals
Published: Oct 11, 2016
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