Mammalian Genome 9, 595–597 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Characterization of murine BCAT genes: Bcat1, a c-Myc target, and its homolog, Bcat2 T. Ben-Yosef, A. Eden, N. Benvenisty Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel Received: 6 October 1997 / Accepted: 4 March 1998 The myc family of proto-oncogenes has been implicated in the regulation of gene transcription (for a review see Amati and Land 1994). All Myc proteins harbor several motifs characteristic of known transcription factors, and together with another nuclear protein, Max, they bind a specific DNA sequence (Blackwell et al. 1990; Blackwood and Eisenman 1991). The pathways by which c-Myc induces cellular processes are still obscure, and targets for Myc activity are largely unknown. Yet, in the past years, several genes have been suggested to be directly regulated by c-Myc (Schmidt 1996). The gene ECA39 (HGMW approved name: Bcat1) was iso- lated by a subtraction/co-expression strategy with c-Myc-induced tumors of transgenic mice, and proved to be a direct genetic target for c-Myc regulation in the mouse (Benvenisty et al. 1992). The Bcat1 gene is highly expressed early in embryogenesis, and during organogenesis
Mammalian Genome – Springer Journals
Published: Jul 1, 1998
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