950 Mammalian Genome 8, Brief Data Reports 12. Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall loci map to different chromosomes. In addition to islet cells, these RJ, Prins J-B, McShane P, Lathrop GM, Peterson LB, Wicker LS, proteins are expressed in other neuroendocrine cells and in brain, Todd JA (1993) Polygenic control of autoimmune diabetes in non- and IA-2 expression has been shown to be upregulated in fibro- obese diabetic mice. Nature Genet 4, 404-409 blasts after mitogenic stimulation . 13. DeSilva M, Jun H, Yoon J, Notkins A, Lan M (1996) Autoantibodies Another receptor-type PTP with demonstrated phosphatase ac- to IA-2 not detected in NOD mice or BB rats. Diabetologia 39, 1237- tivity, Ptprc (CD45), maps at 74 cM on mouse Chr 1, a site considerably distal to the region containing Ptprn. In segregation analysis between the autoimmune IDDM-prone NOD strain and diabetes-resistant C57BL/10 mice, a diabetes susceptibility locus Characterization of a human homolog (Idd5) has been reported to map to the a region of Chr 1 near Ptprn . Mouse Genome Database (MGD) currently shows the Idd5 (OVOL1) of the Drosophila ovo gene, which locus at 40 cM, but this is arbitrary, since
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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