Mammalian Genome 11, 1150–1153 (2000). DOI: 10.1007/s003350010201 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene Stephen Wedgwood, Wai K. Lam, Karen M. Pinchin, Alexander F. Markham, Elizabeth J. Cartwright, P. Louise Coletta Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James’s University Hospital, Leeds LS9 7TF, UK Received: 30 March 2000 / Accepted: 25 July 2000 Germline mutations in the Adenomatous Polyposis Coli (APC) detected in brain were approximately equal. The 10-kb transcript gene are causal in an autosomal dominant form of colorectal can- was also detected in lung, liver, skeletal muscle, kidney, and testis. cer termed familial adenomatous polyposis (FAP; Kinzler et al. The larger 12-kb species was also detected in these tissues, but at 1991; Groden et al. 1991). FAP patients develop hundreds of pol- a much lower intensity than the 10-kb transcript. As the 12-kb yps in the colon, some of which if not surgically removed develop transcript was abundant in brain and present at very low levels in into adenocarcinomas. Germline mutations in APC are also re- all other tissues tested, we have termed this transcript brain- sponsible for
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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