Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene

Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor... Mammalian Genome 11, 1150–1153 (2000). DOI: 10.1007/s003350010201 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene Stephen Wedgwood, Wai K. Lam, Karen M. Pinchin, Alexander F. Markham, Elizabeth J. Cartwright, P. Louise Coletta Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James’s University Hospital, Leeds LS9 7TF, UK Received: 30 March 2000 / Accepted: 25 July 2000 Germline mutations in the Adenomatous Polyposis Coli (APC) detected in brain were approximately equal. The 10-kb transcript gene are causal in an autosomal dominant form of colorectal can- was also detected in lung, liver, skeletal muscle, kidney, and testis. cer termed familial adenomatous polyposis (FAP; Kinzler et al. The larger 12-kb species was also detected in these tissues, but at 1991; Groden et al. 1991). FAP patients develop hundreds of pol- a much lower intensity than the 10-kb transcript. As the 12-kb yps in the colon, some of which if not surgically removed develop transcript was abundant in brain and present at very low levels in into adenocarcinomas. Germline mutations in APC are also re- all other tissues tested, we have termed this transcript brain- sponsible for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene

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Publisher
Springer-Verlag
Copyright
Copyright © 2000 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010201
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 11, 1150–1153 (2000). DOI: 10.1007/s003350010201 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene Stephen Wedgwood, Wai K. Lam, Karen M. Pinchin, Alexander F. Markham, Elizabeth J. Cartwright, P. Louise Coletta Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James’s University Hospital, Leeds LS9 7TF, UK Received: 30 March 2000 / Accepted: 25 July 2000 Germline mutations in the Adenomatous Polyposis Coli (APC) detected in brain were approximately equal. The 10-kb transcript gene are causal in an autosomal dominant form of colorectal can- was also detected in lung, liver, skeletal muscle, kidney, and testis. cer termed familial adenomatous polyposis (FAP; Kinzler et al. The larger 12-kb species was also detected in these tissues, but at 1991; Groden et al. 1991). FAP patients develop hundreds of pol- a much lower intensity than the 10-kb transcript. As the 12-kb yps in the colon, some of which if not surgically removed develop transcript was abundant in brain and present at very low levels in into adenocarcinomas. Germline mutations in APC are also re- all other tissues tested, we have termed this transcript brain- sponsible for

Journal

Mammalian GenomeSpringer Journals

Published: Dec 1, 2000

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