Characterization of 48 polymorphic loci as potential markers for the risk of ischemic stroke

Characterization of 48 polymorphic loci as potential markers for the risk of ischemic stroke With the aim to determine specific genetic characteristics of the population of Moscow region, we determined allele frequencies of 48 polymorphic loci (SNP) associated with the increased risk of ischemic stroke development. The genotype frequency distribution for all the SNPs corresponds to Hardy–Weinberg equilibrium. Comparison of the allele frequencies with those obtained for Caucasian populations from the databases dbSNP and 1000 Genomes Project revealed significant differences for two SNPs (rs556621 and rs556512) and seven SNPs (rs556621, rs556512, rs1801133, rs1799983, rs5918, rs328, and rs2398162), respectively. The revealed genetic features of the population make it possible to increase the accuracy and reliability of the individual genetic risk assessment of development for multifactorial diseases in the examined population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Characterization of 48 polymorphic loci as potential markers for the risk of ischemic stroke

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Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795417060047
Publisher site
See Article on Publisher Site

Abstract

With the aim to determine specific genetic characteristics of the population of Moscow region, we determined allele frequencies of 48 polymorphic loci (SNP) associated with the increased risk of ischemic stroke development. The genotype frequency distribution for all the SNPs corresponds to Hardy–Weinberg equilibrium. Comparison of the allele frequencies with those obtained for Caucasian populations from the databases dbSNP and 1000 Genomes Project revealed significant differences for two SNPs (rs556621 and rs556512) and seven SNPs (rs556621, rs556512, rs1801133, rs1799983, rs5918, rs328, and rs2398162), respectively. The revealed genetic features of the population make it possible to increase the accuracy and reliability of the individual genetic risk assessment of development for multifactorial diseases in the examined population.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jul 12, 2017

References

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